Evidence map›Paper›PMID 29386192›Full record

ArticleBMJ (Clinical research ed.)2018

Cancer risk associated with chronic diseases and disease markers: prospective cohort study.

Huakang Tu, Chi Pang Wen, Shan Pou Tsai, Wong-Ho Chow, Christopher Wen, Yuanqing Ye, Hua Zhao, Min Kuang Tsai, Maosheng Huang, Colin P Dinney and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Cancer risk in Korean patients with gout.The Korean journal of internal medicine · 2022
    Trial
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  11. Antiproliferative and Anti-Inflammatory Activities of Encapsulated Opuntia Peel Polyphenols.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026
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  14. Observational
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Huakang TuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Chi Pang WenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Shan Pou TsaiMJ Health Research Foundation, Taipei, Taiwan.
Wong-Ho ChowDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Christopher WenRadiology, Long Beach Veterans Administration Hospital, University of California at Irvine, CA, USA.
Yuanqing YeDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Hua ZhaoDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Min Kuang TsaiInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Maosheng HuangDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Colin P DinneyDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chwen Keng TsaoMJ Health Management Institution, Taipei, Taiwan.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA xwu@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USCalifornia State University, Long Beach · USChina Medical University Hospital · TWNational Health Research Institutes · TW

Funding

Molecular pathways linking obesity and RCC tumorigenesis (PQ1)R01CA170298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GU, JIAN · 2012 to 2015
$2.1M
(PQA4) Point-of-Care Test of Exposure to Hepatocellular Carcinoma Risk by V-ChipR01CA180083 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI QIN, LIDONG, WU, XIFENG · 2013 to 2016
$2.1M
NCI NIH HHS R01 CA170298NCI NIH HHS R01 CA180083
6 · The paper itself

Abstract

objectivesTo assess the independent and joint associations of major chronic diseases and disease markers with cancer risk and to explore the benefit of physical activity in reducing the cancer risk associated with chronic diseases and disease markers.

designProspective cohort study.

settingStandard medical screening program in Taiwan.

participants405 878 participants, for whom cardiovascular disease markers (blood pressure, total cholesterol, and heart rate), diabetes, chronic kidney disease markers (proteinuria and glomerular filtration rate), pulmonary disease, and gouty arthritis marker (uric acid) were measured or diagnosed according to standard methods, were followed for an average of 8.7 years.

main outcome measuresCancer incidence and cancer mortality.

resultsA statistically significantly increased risk of incident cancer was observed for the eight diseases and markers individually (except blood pressure and pulmonary disease), with adjusted hazard ratios ranging from 1.07 to 1.44. All eight diseases and markers were statistically significantly associated with risk of cancer death, with adjusted hazard ratios ranging from 1.12 to 1.70. Chronic disease risk scores summarizing the eight diseases and markers were positively associated with cancer risk in a dose-response manner, with the highest scores associated with a 2.21-fold (95% confidence interval 1.77-fold to 2.75-fold) and 4.00-fold (2.84-fold to 5.63-fold) higher cancer incidence and cancer mortality, respectively. High chronic disease risk scores were associated with substantial years of life lost, and the highest scores were associated with 13.3 years of life lost in men and 15.9 years of life lost in women. The population attributable fractions of cancer incidence or cancer mortality from the eight chronic diseases and markers together were comparable to those from five major lifestyle factors combined (cancer incidence: 20.5%

conclusionsChronic disease is an overlooked risk factor for cancer, as important as five major lifestyle factors combined. In this study, chronic diseases contributed to more than one fifth of the risk for incident cancer and more than one third of the risk for cancer death. Physical activity is associated with a nearly 40% reduction in the cancer risk associated with chronic diseases.

Indexed as

AdultArthritis, GoutyBiomarkersCardiovascular DiseasesChronic DiseaseDiabetes ComplicationsDiabetes MellitusEarly Detection of CancerExerciseFemaleHumansIncidenceLife StyleLung DiseasesMaleMiddle AgedBiomarkers

Identifiers

PMID29386192
PMCPMC5791146
OpenAlexW2786750066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.