Evidence map›Paper›PMID 29386110›Full record

ArticleCell reports2018

Temporal Control of Metabolic Amplitude by Nocturnin.

Jeremy J Stubblefield, Peng Gao, Gokhul Kilaru, Bilal Mukadam, Jeremy Terrien, Carla B Green

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Coordination of rhythmic RNA synthesis and degradation orchestrates 24- and 12-h RNA expression patterns in mouse fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
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  14. Review
  15. Circadian rhythm as a therapeutic target.Nature reviews. Drug discovery · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jeremy J StubblefieldDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address: stubblefiej3@uthscsa.edu.
Peng GaoDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Gokhul KilaruDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Bilal MukadamDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Jeremy TerrienDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA.
Carla B GreenDepartment of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address: carla.green@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Molecular mechanisms of mammalian circadian clock function - Renewal - 1R35GM127122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Carla B. Green · 2018 to 2026
$6.0M
Transcriptional Architecture and Chromatin Landscape of Circadian Clocks in AgingR01AG045795 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI GREEN, CARLA B., TAKAHASHI, JOSEPH S · 2013 to 2017
$1.5M
Circadian regulation of mitochondrial RNA polyadenylationR01GM111387 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GREEN, CARLA B. · 2014 to 2017
$1.2M
Circadian dynamics of cytoplasmic mRNA polyadenylation and deadenylationR01GM112991 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GREEN, CARLA B. · 2016 to 2018
$1.1M
NHLBI NIH HHS T32 HL007446NIA NIH HHS R01 AG045795NIGMS NIH HHS R01 GM111387NIGMS NIH HHS R01 GM112991NIGMS NIH HHS R35 GM127122
6 · The paper itself

Abstract

The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Nocturnin as a regulator of metabolic amplitude across the day/night cycle and in response to nutrient challenge. We show that mice lacking Nocturnin (Noct

Indexed as

AnimalsCholesterolCircadian RhythmLipid MetabolismLiverMaleMiceMice, Inbred C57BLMice, KnockoutNuclear ProteinsRNA, MessengerTranscription FactorsCholesterolnocturninNuclear ProteinsRNA, MessengerTranscription Factorsamplitudecholesterolcircadiandeadenylationlipidnocturninobesitypoly(A)

Identifiers

PMID29386110
PMCPMC5815321
OpenAlexW2785367402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.