Evidence map›Paper›PMID 29386093›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2018

Incidence and seasonality of respiratory syncytial virus hospitalisations in young children in Denmark, 2010 to 2015.

Martin T Jepsen, Ramona Trebbien, Hanne Dorthe Emborg, Tyra G Krause, Kristian Schønning, Marianne Voldstedlund, Jens Nielsen, Thea K Fischer

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  12. Inpatient burden of respiratory syncytial virus (RSV) in Switzerland, 2003 to 2021: an analysis of administrative data.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
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  14. Observational
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  17. Estimating the Incidence of First RSV Hospitalization in Children Born in Ontario, Canada.Journal of the Pediatric Infectious Diseases Society · 2023
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  18. Article
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  20. Early and intense epidemic of respiratory syncytial virus (RSV) in Denmark, August to December 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Martin T JepsenStatens Serum Institut, Copenhagen S, Denmark.
Ramona TrebbienStatens Serum Institut, Copenhagen S, Denmark.
Hanne Dorthe EmborgStatens Serum Institut, Copenhagen S, Denmark.
Tyra G KrauseStatens Serum Institut, Copenhagen S, Denmark.
Kristian SchønningDepartment of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark.
Marianne VoldstedlundStatens Serum Institut, Copenhagen S, Denmark.
Jens NielsenStatens Serum Institut, Copenhagen S, Denmark.
Thea K FischerStatens Serum Institut, Copenhagen S, Denmark.
Statens Serum Institut · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For future decisions on respiratory syncytial virus (RSV)-vaccination strategies and implementation into national immunisation-programmes, we used national registry data (hospitalisation, microbiology and vital statistics) to determine the age-specific incidence and direct medical costs of annual RSV-associated admissions in children < 5 years-old for the period of 2010-2015. We identified ca 2,500 RSV-associated hospitalisations annually amounting to total direct medical-costs of ca EUR 4.1 million per year. The incidence of RSV-associated hospitalisations peaked in infants 1-2 months of age followed by infants 2-3 months of age, and infants < 1 month of age, respectively. Infant boys were at higher risk of severe RSV infection as compared to infant girls: male-to-female ratio peaked with 1.4 at four months of age and gradually levelled out with increasing age to 1.0 at 4 years of age. Five RSV-associated deaths were identified. Our findings demonstrate that in a western country as Denmark, RSV constitutes a considerable burden on childhood health. Furthermore, the best approach to reduce the high incidence of RSV-associated hospitalisations in young infants < 3 months of age may be maternal vaccination due to general challenges in achieving sufficient and protective immune responses in young infants.

Indexed as

Health Care CostsSeasonsChild, PreschoolDenmarkFemaleHospitalizationHumansInfantInfant, NewbornMalePopulation SurveillanceRegistriesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRetrospective StudiesSex Distributioncost-benefitdisease burdenincidenceRespiratory syncytial virusRSV

Identifiers

PMID29386093
PMCPMC5792699
OpenAlexW2793193858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.