Evidence map›Paper›PMID 29386085›Full record

ArticleGenetics research2018

DNA methylation is not involved in dietary restriction induced lifespan extension in adult Drosophila.

Ting Lian, Uma Gaur, Q I Wu, Jianbo Tu, Boyuan Sun, Deying Yang, Xiaolan Fan, Xueping Mao, Mingyao Yang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Aging mechanisms-A perspective mostly fromAdvanced genetics (Hoboken, N.J.) · 2020
    Article
  2. The Epigenetics of Aging in Invertebrates.International journal of molecular sciences · 2019
    Review
  3. The Impact of Caloric Restriction on the Epigenetic Signatures of Aging.International journal of molecular sciences · 2019
    Review
  4. Genes & nutrition · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ting LianInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Uma GaurInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Q I WuInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Jianbo TuInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Boyuan SunInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Deying YangInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Xiaolan FanInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Xueping MaoInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Mingyao YangInstitute of Animal Genetics and Breeding,Sichuan Agricultural University,Chengdu,Sichuan, 611130,P. R. China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary restriction (DR) is widely regarded as a viable intervention to extend lifespan and healthspan in diverse organisms. The precise molecular regulatory mechanisms are largely unknown. Epigenetic modifications are not stable upon DR and also keep changing with age. Here, we employed whole genome bisulfite sequencing to determine the DNA methylation changes upon DR in adult Drosophila. Our results indicate that although a low level of DNA methylation exists in the adult Drosophila genome, there is no significant difference in DNA methylation levels upon DR when compared to unrestricted flies. This suggests that other epigenetic components such as histone modifications might be altered by DR.

Indexed as

DietDNA MethylationAnimalsCaloric RestrictionCytosineDrosophilaEpigenesis, GeneticFemaleGenome, InsectLongevityCytosine

Identifiers

PMID29386085
PMCPMC6865161
OpenAlexW2794417060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.