ArticleBMC complementary and alternative medicine2018
The association between cold hypersensitivity in the hands and feet and chronic disease: results of a multicentre study.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- The Immediate Effect of Sinapis nigra and Zingiber officinale as Thermogenic Substances during Footbaths: A Randomized Controlled Crossover Trial.Complementary medicine research · 2022Trial
- Cold Extremities and Underweight as a Combined Risk Profile for Open-Angle Glaucoma: A Population-Based Cross-Sectional Study in Korea.Medicina (Kaunas, Lithuania) · 2026Article
- Regulation ofGenes & diseases · 2026Article
- A new biomarker for screening Hiesho (cold hypersensitivity) in young females through measurement of the foot temperature-recovery rate after a cooling test.BMC women's health · 2025Article
- Cold hypersensitivity in the lower extremities: an underappreciated symptom in patients with varicose veins.Open heart · 2025Article
- Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet.Journal of pharmacopuncture · 2025Article
- Observational
- Sex-related differences regarding headache triggered by low barometric pressure in Japan.BMC research notes · 2024Article
- Cold sensitivity among female clinical nurses in Japan: A nationwide study.International journal of nursing studies advances · 2024Article
- Cold hypersensitivity in the hands and feet is associated with erectile dysfunction in young Taiwanese men.Scientific reports · 2024Article
- Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden.Scientific reports · 2024Article
- Systematic Analysis of the Molecular Mechanisms of Cold and Hot Properties of Herbal Medicines.Plants (Basel, Switzerland) · 2022Article
- Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management.The EPMA journal · 2022Article
- Segmental bioelectrical impedance analysis for Korean older population with cold pattern.Frontiers in nutrition · 2022Article
- Efficacy and safety of sympathetic radiofrequency thermocoagulation in the treatment of cold hypersensitivity.Frontiers in neurology · 2022Article
- Herbal Medicine for Patients with Cognitive Impairment: An Observational Study.Neuropsychiatric disease and treatment · 2021Article
- Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments.The EPMA journal · 2019Article
- The Relationship between Cold Hypersensitivity in the Hands and Feet and Health-Related Quality of Life in Koreans: A Nationwide Population Survey.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Are cold extremities an issue in women's health? Epidemiological evaluation of cold extremities among Japanese women.International journal of women's health · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCold hypersensitivity in the hands and feet (CHHF) is a common symptom in Korea and patients with CHHF complain of coldness in the hands and feet in an environment that is not considered cold by unaffected people. In traditional East Asian medicine, CHHF is believed to be accompanied by various diseases and symptoms, and is considered a symptom that needs active treatment. CHHF is used for pattern identification in the cold pattern, yang deficiency, and constitution. This study aimed to examine the differences in frequencies of chronic diseases with respect to the presence of CHHF.
methodsDisease history, CHHF, body measurements, and blood test survey data from 6149 patients collected by 25 medical institutes in Korea were obtained from the Korean Medicine Data Center. The participants were divided into CHHF (n = 1909) and non-CHHF groups (n = 3017) according to the CHHF survey. The differences in frequencies of 18 diseases were analysed using chi-square tests, and the odds ratios (ORs) for each disease according to CHHF status were examined via logistic regression with adjustment for age, sex, and body mass index (BMI).
resultsBased on chi-square test results, the CHHF group showed a higher frequency of the following diseases: anaemia, hypotension, chronic gastritis, reflux oesophagitis, chronic rhinitis, dysmenorrhoea, and gastroduodenal ulcer. Diseases found in lower frequencies were as follows: hypertension, diabetes mellitus, impaired fasting glucose, dyslipidaemia, stroke, fatty liver, and angina pectoris. In addition, from the logistic regression with adjustment for age, sex, and BMI, the CHHF group showed a lower OR in diabetes mellitus and dyslipidaemia than the non-CHHF group, but a higher OR in degenerative arthritis, chronic gastritis, gastroduodenal ulcer, reflux oesophagitis, and chronic rhinitis.
conclusionsThis study showed that CHHF is associated with chronic disease. Further large-scale prospective studies are needed to validate these associations.
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