ReviewNeurosurgical focus2018
Neuromodulation with transcranial focused ultrasound.
Review in Neurosurgical focus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Noninvasive Brain Stimulation on Mental States, Behavior, and Electrophysiology
Altering Default Mode Network Activity to Reduce Depressive Symptoms
Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Modulatory Effects by Low-Intensity Transcranial Ultrasound Stimulation (TUS): A Systematic Review on Both Animal and Human Studies.Frontiers in neuroscience · 2019Pooled it
- Noninvasive Modulation of the Subcallosal Cingulate and Depression With Focused Ultrasonic Waves.Biological psychiatry · 2025Trial
- Real time and delayed effects of subcortical low intensity focused ultrasound.Scientific reports · 2021Trial
- Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation.CNS neuroscience & therapeutics · 2026Review
- Review
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system.Neural regeneration research · 2026Article
- Piezo1-Targeted Magnetoacoustic Nanobubbles Rescue Alzheimer's Pathology by Electromechanical Neuromodulation and Amyloid-β Clearance.ACS nano · 2026Article
- Alternating-contrast single-shot spiral MR-ARFI with model-based displacement map reconstruction.Magnetic resonance in medicine · 2026Article
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Unlocking a Novel Therapeutic Modality: Low-Intensity Transcranial Ultrasound as a Key to CNS Treatment - A Bibliometric and Systematic Review.Journal of central nervous system disease · 2026Review
- Transcranial ultrasound stimulation selectively enhances fronto-temporal context-guided memory.bioRxiv : the preprint server for biology · 2025Article
- Magnitude preparation-based MR-acoustic radiation force imaging.Magnetic resonance in medicine · 2025Article
- Focused Modulation of Brain Activity: A Narrative Review.Biomedicines · 2025Review
- Low intensity trans-spinal focused ultrasound reduces mechanical sensitivity and suppresses spinal microglia activation in rats with chronic constriction injury.Bioelectronic medicine · 2025Article
- Focused Ultrasound: Noninvasive Image-Guided Therapy.Investigative radiology · 2025Review
- Flexible micromachined ultrasound transducers (MUTs) for biomedical applications.Microsystems & nanoengineering · 2025Review
- Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches.Cells · 2025Review
- Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature.Communications biology · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The understanding of brain function and the capacity to treat neurological and psychiatric disorders rest on the ability to intervene in neuronal activity in specific brain circuits. Current methods of neuromodulation incur a tradeoff between spatial focus and the level of invasiveness. Transcranial focused ultrasound (FUS) is emerging as a neuromodulation approach that combines noninvasiveness with focus that can be relatively sharp even in regions deep in the brain. This may enable studies of the causal role of specific brain regions in specific behaviors and behavioral disorders. In addition to causal brain mapping, the spatial focus of FUS opens new avenues for treatments of neurological and psychiatric conditions. This review introduces existing and emerging FUS applications in neuromodulation, discusses the mechanisms of FUS effects on cellular excitability, considers the effects of specific stimulation parameters, and lays out the directions for future work.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.