Evidence map›Paper›PMID 29385888›Full record

ArticlePharmaceutical biology2018

Andrographolide relieved pathological pain generated by spared nerve injury model in mice.

Huang-Chi Wang, Hsin-Sheng Tsay, Hui-Nung Shih, Yi-An Chen, Kai-Ming Chang, Dinesh Chandra Agrawal, Siendong Huang, Yi-Lo Lin, Meng-Jen Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Huang-Chi Wanga Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.
Hsin-Sheng Tsaya Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.
Hui-Nung Shiha Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.
Yi-An Chena Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.
Kai-Ming Changb Department of Research , Koo Foundation Sun Yat-Sen Cancer Center , Taipei , Taiwan , ROC.
Dinesh Chandra Agrawala Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.
Siendong Huangc Department of Applied Mathematics , National Dong Hwa University , Hualien , Taiwan , ROC.
Yi-Lo Lind Graduate Institute of Veterinary Pathobiology , National Chung Hsing University , Taichung , Taiwan , ROC.
Meng-Jen Leea Department of Applied Chemistry , Chaoyang University of Technology , Taichung , Taiwan , ROC.ORCID http://orcid.org/0000-0002-5332-8806
Chaoyang University of Technology · TWKoo Foundation Sun Yat-Sen Cancer Center · TWNational Chung Hsing University · TWNational Dong Hwa University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextAndrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia.

objectiveThe objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model. MATERIAL AND

methodsMale 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group). Andro or NSAIDS (diclofenac salt) were injected intraperitoneally at 5 mg/kg body weight daily. Mechanical allodynia was assessed by von Frey tests at 3, 7, and 14 d. For immunohistochemical analysis, samples were collected at 7 d.

resultsThe threshold for inducing allodynia increased and the response percentage reduced in the Andro-group when compared with the Saline-group, as well as when compared with NSAIDS groups throughout 3-14 d. The ratio of threshold for OP-Andro/OP-saline and for OP-Andro/OP-NSAIDS groups was 20.42 and 11.67 at 14 d, respectively. The ratio of response percentage for OP-Andro/OP-saline and for OP-Andro/OP-NSAIDS was 0.32 and 0.39 at 14 d, respectively. Interleukin-1 (IL-1) immunostaining in the spinal cord was reduced in the Andro-group. Astrocytic activities were not significantly reduced in the Andro-group compared with the Saline-group at 7 d post-operation (PO) Conclusions: Andro reduced mechanical allodynia more than NSAIDS at the same concentration, and the observed behaviour was associated with a reduction in inflammatory cytokine produced in the spinal cord.

Indexed as

Disease Models, AnimalAnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDiterpenesHyperalgesiaMaleMiceMice, Inbred BALB CPainSciatic NeuropathyandrographolideAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDiterpenesAllodyniaAndrographis paniculataastrocytesIL-1von Frey test

Identifiers

PMID29385888
PMCPMC6130553
OpenAlexW2790665122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.