Evidence map›Paper›PMID 29385887›Full record

ArticleNanotoxicology2018

Short-term inhalation study of graphene oxide nanoplates.

Young Hun Kim, Mi Seong Jo, Jin Kwon Kim, Jae Hoon Shin, Jin Ee Baek, Hye Seon Park, Hyo Jin An, Jong Seong Lee, Boo Wook Kim, Hoi Pin Kim and 7 more

Open access · greenAbstract read
In one paragraph

Article in Nanotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Dustiness of graphene and graphite.Journal of occupational and environmental hygiene · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Hepatotoxicity of graphene oxide in Wistar rats.Environmental science and pollution research international · 2021
    Article
  15. Article
  16. Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe-by-Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Young Hun Kima Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Mi Seong Joa Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Jin Kwon Kima Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Jae Hoon Shinb Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service , Incheon , Korea.
Jin Ee Baekb Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service , Incheon , Korea.
Hye Seon Parka Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Hyo Jin Ana Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Jong Seong Leeb Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service , Incheon , Korea.
Boo Wook Kimb Occupational Lung Diseases Institute, Korea Workers' Compensation and Welfare Service , Incheon , Korea.
Hoi Pin Kima Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Kang Ho Ahnc Department of Mechanical Engineering , Hanyang University , Ansan , Korea.
KiSoo Jeond HCTm, Co. Ltd. , Icheon , Korea.
Seung Min Oha Department of Nanofusion Technology , Hoseo University , Asan , Korea.
Ji Hyun Leee Institute for Risk Analysis and Risk Communication , University of Washington , Seattle , WA , USA.
Tomomi Workmane Institute for Risk Analysis and Risk Communication , University of Washington , Seattle , WA , USA.
Elaine M Faustmane Institute for Risk Analysis and Risk Communication , University of Washington , Seattle , WA , USA.
Il Je Yud HCTm, Co. Ltd. , Icheon , Korea.
Hoseo University · KRUniversity of Washington · USHanyang University · KR

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Project 3: Integrative Risk Assessment Methods for Engineered NanomaterialsU19ES019545 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAVANAGH, TERRANCE J · 2010 to 2014
$5.6M
EPA R835738NIEHS NIH HHS P30 ES007033NIEHS NIH HHS U19 ES019545
6 · The paper itself

Abstract

Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term graphene oxide inhalation toxicity analysis using a nose-only inhalation exposure system and male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0.76 ± 0.16 mg/m

Indexed as

Administration, InhalationAnimalsBiomarkersBronchoalveolar Lavage FluidCytokinesGraphiteInhalation ExposureKidneyLeukocyte CountLiverLungMacrophages, AlveolarMaleNanostructuresOrgan SizeOxidesBiomarkersCytokinesGraphiteOxidesGraphene oxidenose-only inhalation exposure systemshort-term inhalation studytoxicology

Identifiers

PMID29385887
PMCPMC6141029
OpenAlexW2790316444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.