Evidence map›Paper›PMID 29385884›Full record

ArticlePharmaceutical biology2018

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC-MS/MS.

Chengyin Zhang, Zhiqiang Gao, Lijuan Niu, Xuexun Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chengyin Zhanga Department of Nephrology , Yidu Central Hospital of Weifang , Weifang , China.
Zhiqiang Gaoa Department of Nephrology , Yidu Central Hospital of Weifang , Weifang , China.
Lijuan Niua Department of Nephrology , Yidu Central Hospital of Weifang , Weifang , China.
Xuexun Chenb Department of Nephrology , Affiliated Hospital of Weifang Medical University , Weifang , China.
Yidu Central Hospital of Weifang · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTriptolide and amlodipine are often simultaneously used for reducing urine protein excretion after renal transplantation in China clinics.

objectiveThis study investigated the effects of triptolide on the pharmacokinetics of amlodipine in male Sprague-Dawley rats. MATERIALS AND

methodsThe pharmacokinetics of amlodipine (1 mg/kg) with or without triptolide pre-treatment (2 mg/kg/day for seven days) were investigated using a sensitive and reliable LC-MS/MS method. Additionally, the inhibitory effects of triptolide on the metabolic stability of amlodipine were investigated using rat liver microsome incubation systems.

resultsThe results indicated that when the rats were pre-treated with triptolide, the C

conclusionsIn conclusion, these results indicated that triptolide could affect the pharmacokinetics of amlodipine, possibly by inhibiting the metabolism of amlodipine in rat liver when they are co-administered.

Indexed as

AmlodipineAnimalsAntihypertensive AgentsChromatography, LiquidDiterpenesDrug InteractionsEpoxy CompoundsImmunosuppressive AgentsMaleMicrosomes, LiverPhenanthrenesRandom AllocationRatsRats, Sprague-DawleyTandem Mass SpectrometryAmlodipineAntihypertensive AgentsDiterpenesEpoxy CompoundsImmunosuppressive AgentsPhenanthrenestriptolideCYP3A4Herb–drug interactionmetabolism

Identifiers

PMID29385884
PMCPMC6130517
OpenAlexW2792371826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.