Evidence map›Paper›PMID 29385755›Full record

ReviewMolecules (Basel, Switzerland)2018

Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery.

Narottam Lamichhane, Thirupandiyur S Udayakumar, Warren D D'Souza, Charles B Simone, Srinivasa R Raghavan, Jerimy Polf, Javed Mahmood

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 292 citations in OpenAlex.

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  11. Nanoparticles as an Encouraging Therapeutic Approach to Alzheimer's Disease.International journal of molecular sciences · 2025
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Narottam LamichhaneDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. narottamlamichhane@umm.edu.
Thirupandiyur S UdayakumarDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. tudayakumar@med.miami.edu.
Warren D D'SouzaDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. wdsouza@som.umm.edu.
Charles B SimoneDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. CharlesSimone@umm.edu.
Srinivasa R RaghavanDepartment of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA. sraghava@umd.edu.
Jerimy PolfDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. jpolf@umm.edu.
Javed MahmoodDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. jmahmood@som.umaryland.edu.
University of Maryland, Baltimore · USUniversity of Maryland, College Park · USUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes have been extensively studied and are used in the treatment of several diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while avoiding or minimizing rapid degradation and side effects, prolonging the biological half-life and reducing toxicity. The unique feature of liposomes is that they are biocompatible and biodegradable lipids, and are inert and non-immunogenic. Liposomes can compartmentalize and solubilize both hydrophilic and hydrophobic materials. All these properties of liposomes and their flexibility for surface modification to add targeting moieties make liposomes more attractive candidates for use as drug delivery vehicles. There are many novel liposomal formulations that are in various stages of development, to enhance therapeutic effectiveness of new and established drugs that are in preclinical and clinical trials. Recent developments in multimodality imaging to better diagnose disease and monitor treatments embarked on using liposomes as diagnostic tool. Conjugating liposomes with different labeling probes enables precise localization of these liposomal formulations using various modalities such as PET, SPECT, and MRI. In this review, we will briefly review the clinical applications of liposomal formulation and their potential imaging properties.

Indexed as

AnimalsHumansLiposomesMagnetic Resonance ImagingPositron-Emission TomographySingle Photon Emission Computed Tomography Computed TomographyLiposomesclinical applicationsimage guidanceliposomesMRIPETradioisotopesSPECT

Identifiers

PMID29385755
PMCPMC6017282
OpenAlexW2791490604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.