Evidence map›Paper›PMID 29385674›Full record

ArticleMolecules and cells2018

Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells.

Junwon Lee, Sang-Hwi Choi, Dongjin R Lee, Dae-Sung Kim, Dong-Wook Kim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Junwon LeeDepartment of Physiology, Yonsei University College of Medicine, Seoul 03722, Korea.
Sang-Hwi ChoiDepartment of Physiology, Yonsei University College of Medicine, Seoul 03722, Korea.
Dongjin R LeeDepartment of Physiology, Yonsei University College of Medicine, Seoul 03722, Korea.
Dae-Sung KimDepartment of Biotechnology, Brain Korea 21 PLUS Project for Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
Dong-Wook KimDepartment of Physiology, Yonsei University College of Medicine, Seoul 03722, Korea.
Yonsei University · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to induce the production of isthmic organizer (IsO)-like cells capable of secreting fibroblast growth factor (FGF) 8 and WNT1 from human embryonic stem cells (ESCs). The precise modulation of canonical Wnt signaling was achieved in the presence of the small molecule CHIR99021 (0.6 μM) during the neural induction of human ESCs, resulting in the differentiation of these cells into IsO-like cells having a midbrain-hindbrain border (MHB) fate in a manner that recapitulated their developmental course

Indexed as

Cell DifferentiationCell LineEngrailed 2 ProteinFibroblast Growth Factor 8Gene Expression ProfilingHomeodomain ProteinsHuman Embryonic Stem CellsHumansNerve Tissue ProteinsNeuronsPAX5 Transcription FactorPyridinesPyrimidinesWnt1 ProteinChir 99021EN1 protein, humanEngrailed 2 ProteinFGF8 protein, humanFibroblast Growth Factor 8Homeodomain ProteinsNerve Tissue ProteinsPAX5 protein, humanPAX5 Transcription FactorPyridinesPyrimidinesWnt1 ProteinFGFhuman pluripotent stem cellsisthmic organizerneural differentiationWnt

Identifiers

PMID29385674
PMCPMC5824020
OpenAlexW2915931577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.