ArticleSchizophrenia bulletin2019
Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis.Translational psychiatry · 2021Pooled it
- Frontal lobe functioning during a simple response conflict task in first-episode psychosis and its relationship to treatment response.Brain imaging and behavior · 2019Trial
- Inhibitory control deficits and ventral attention network alterations linked to apathy in schizophrenia.Translational psychiatry · 2026Article
- Dorsal anterior cingulate cortex-targeted transcranial temporal interference stimulation for negative symptoms and cognitive impairment in schizophrenia: a participant- and assessor-blinded, sham-controlled randomized controlled trial protocol.Frontiers in psychiatry · 2026Article
- Dual-pathway inhibitory dysfunction in schizophrenia: MEG and behavioral markers for risk stratification.Journal of psychiatry & neuroscience : JPN · 2026Article
- Response Inhibition in Autistic Children Predicts Positive Psychotic Symptoms in Young Adulthood-Results from an 8-Year Follow-up Study.Journal of autism and developmental disorders · 2025Article
- Hierarchical Organization of Bilateral Prefrontal-Basal Ganglia Circuits for Response Inhibition Control.Human brain mapping · 2025Article
- Altered Neural Activation in First Episode Psychosis Patients With Comorbid Conduct Disorder: A Pilot Investigation.JAACAP open · 2025Article
- Effects of repetitive transcranial magnetic stimulation on inhibitory control in first-episode schizophrenia: behavioral and neural mechanisms.Frontiers in psychiatry · 2024Article
- Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.Psychological medicine · 2023Article
- Cognitive Control System Gates Insula Processing of Affective Stimuli in Early Psychosis.Schizophrenia bulletin · 2023Article
- Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis.Journal of neurodevelopmental disorders · 2023Review
- Characterizing different cognitive and neurobiological profiles in a community sample of children using a non-parametric approach: An fMRI study.Developmental cognitive neuroscience · 2023Article
- Early cognitive comorbidities before disease onset: A common symptom towards prevention of related brain diseases?Heliyon · 2022Review
- Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder.Psychiatry research. Neuroimaging · 2022Article
- Altered effective connectivity within an oculomotor control network in individuals with schizophrenia.NeuroImage. Clinical · 2021Article
- Stability of mismatch negativity event-related potentials in a multisite study.International journal of methods in psychiatric research · 2020Article
- Intrinsic Connectivity of the Globus Pallidus: An Uncharted Marker of Functional Prognosis in People With First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- Machine Learning-Based Identification of Suicidal Risk in Patients With Schizophrenia Using Multi-Level Resting-State fMRI Features.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Response inhibition (RI) is a component of the cognitive control systems that support optimal cognition. Cognitive control deficits are well-described in schizophrenia, but are not well characterized in individuals at clinical high risk (CHR) for developing psychosis. Functional magnetic resonance imaging during Go/NoGo task performance was collected from 30 CHR youth, 23 early illness schizophrenia patients (ESZ), and 72 healthy adolescents and young adults (HC). Voxelwise main effects of group were examined (P < .005 height threshold, family-wise error-corrected cluster threshold, P < .05) for correct NoGo-Go contrast values and task-based functional connectivity. CHR and ESZ groups had slower and more variable reaction times (RT) on Go trials compared to HCs. Significant main effects of group in bilateral dorsal anterior cingulate (dACC) and right inferior frontal cortex stemmed from CHR and ESZ groups showing significantly less NoGo-Go activation, relative to HCs. Faster responding HCs had less functional coupling between dACC and medial prefrontal cortex, a default mode network (DMN) region during NoGo vs Go trials. This functional connectivity-performance relationship was not present in ESZ or CHR groups. The pattern of findings suggests CHR and ESZ groups were deficient in developing strong and consistent prepotent responding, based on their slow and variable motor responses and decreased engagement of dACC and right inferior frontal regions implicated in inhibitory control. Furthermore, only the control group showed a functional connectivity relationship consistent with greater response prepotency requiring more decoupling of inhibitory control regions from DMN regions during RI.
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