ArticleSocial cognitive and affective neuroscience2018
Outgroup emotion processing in the vACC is modulated by childhood trauma and CACNA1C risk variant.
Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Do Adverse Childhood Experiences Make Us More Utilitarian in Moral Dilemmas?Psychology research and behavior management · 2024Article
- Social Behavior and Ultrasonic Vocalizations in a Genetic Rat Model Haploinsufficient for the Cross-Disorder Risk GeneBrain sciences · 2021Review
- Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants.Social cognitive and affective neuroscience · 2020Article
- Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task.European archives of psychiatry and clinical neuroscience · 2020Article
- Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium.European archives of psychiatry and clinical neuroscience · 2019Article
- Effects of childhood trauma on adult moral decision-making: Clinical correlates and insights from bipolar disorder.Journal of affective disorders · 2019Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
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Abstract
A high frequency of outgroup contact-as experienced by urban dwellers and migrants-possibly increases schizophrenia risk. This risk might be further amplified by genetic and environmental risk factors, such as the A-allele of rs1006737 within the calcium voltage-gated channel subunit alpha1 C gene and childhood interpersonal trauma (CIT). Both have been related to ventral anterior cingulate cortex (vACC) functioning. We investigated vACC functioning, during ingroup and outgroup emotion perception in relation to rs1006737 and CIT. Group membership was manipulated through a minimal group paradigm. Thus, in our functional magnetic resonance imaging study, a group of healthy Caucasian participants (n = 178) viewed video-recorded facial emotions (happy vs angry) of actors artificially assigned to represent the ingroup or the outgroup. Rs1006737 and CIT were related to brain activation for group and emotion specific processing. The group-emotion interaction in the vACC showed reduced sensitivity to emotional valence for outgroup member processing. Specifically for the angry outgroup condition, we found a gene by environment interaction in vACC activity. We speculate that the increased schizophrenia risk in migrants and urban dwellers could therefore be facilitated via this pathophysiological pathway.
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