Evidence map›Paper›PMID 29385540›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance.

Albert M Anderson, William R Tyor, Mark J Mulligan, Drenna Waldrop-Valverde, Jeffrey L Lennox, Scott L Letendre

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Albert M AndersonDepartment of Medicine, Atlanta.
William R TyorDepartment of Neurology, Atlanta.
Mark J MulliganDepartment of Medicine, Atlanta.
Drenna Waldrop-ValverdeEmory University Nell Hodgson Woodruff School of Nursing, Atlanta, Georgia.
Jeffrey L LennoxDepartment of Medicine, Atlanta.
Scott L LetendreDepartments of Medicine and Psychiatry, University of California at San Diego, La Jolla.
University of Atlanta · USAtlanta VA Health Care System · USEmory University · USUniversity of California, San Diego · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)U01AI047996 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOEPFERT, PAUL A. · 2000 to 2006
$8.4M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
Study of zidovudine addition in HIV-associated neurocognitive disordersK23MH095679 · NIMH · EMORY UNIVERSITY · PI ANDERSON, ALBERT · 2013 to 2017
$899k
NIAID NIH HHS P30 AI050409NIAID NIH HHS U01 AI047996NIMH NIH HHS K23 MH095679NIMH NIH HHS K24 MH097673NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 concentration and worse neuropsychological performance.

Indexed as

AdultEnzyme-Linked Immunosorbent AssayFemaleHIV-1HIV Core Protein p24HIV InfectionsHumansMaleMiddle AgedNeurocognitive DisordersNeuropsychological TestsRNA, ViralHIV Core Protein p24RNA, Viral

Identifiers

PMID29385540
PMCPMC6005050
OpenAlexW2793668363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.