ArticleGenome biology and evolution2018
Multiple Acquisitions of Pathogen-Derived Francisella Endosymbionts in Soft Ticks.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Genomic Evolution of Francisella: Metabolic Innovation, Endosymbiotic Transitions to Ticks, and Biogeographic History.Genome biology and evolution · 2026Article
- Molecular detection and phylogenetic characterization of pathogenic and endosymbiont microorganisms in Hyalomma ticks collected from livestock.Parasites & vectors · 2026Article
- Country-wide assessment of tick-borne pathogens collected in ticks between 2021 and 2024 in Germany, with a focus onOne health (Amsterdam, Netherlands) · 2025Article
- The role of deer keds (Diptera: Hippoboscidae: Lipoptena and Neolipoptena) in occupational and public health.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Host-Specificity and Network Structure of Tick Microbiota in Co-Distributed Species From the Iberian Peninsula.Ecology and evolution · 2025Article
- Microbiome-based surveillance of zoonotic tick-borne pathogens from urban wild boars in Barcelona, 2022-2023.One health (Amsterdam, Netherlands) · 2025Article
- Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025Article
- Host-bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts.FEMS microbiology reviews · 2024Review
- Impact of endosymbionts on tick physiology and fitness.Parasitology · 2023Review
- Diversity of the Bacterial and Viral Communities in the Tropical Horse Tick,Pathogens (Basel, Switzerland) · 2023Article
- Diversity of the bacterial and viral communities in the tropical horse tick,bioRxiv : the preprint server for biology · 2023Article
- The Biological and Ecological Features of Northbound Migratory Birds, Ticks, and Tick-Borne Microorganisms in the African-Western Palearctic.Microorganisms · 2023Review
- Article
- Co-Occurrence ofMicroorganisms · 2022Article
- Ecological Contacts and Host Specificity Promote Replacement of Nutritional Endosymbionts in Ticks.Microbial ecology · 2022Article
- Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples.PloS one · 2022Article
- The Symbiotic Continuum Within Ticks: Opportunities for Disease Control.Frontiers in microbiology · 2022Review
- Assessing Temporal Changes in Microbial Communities inFrontiers in veterinary science · 2022Article
- Novel symbionts and potential human pathogens excavated from argasid tick microbiomes that are shaped by dual or single symbiosis.Computational and structural biotechnology journal · 2022Article
- A dual endosymbiosis supports nutritional adaptation to hematophagy in the invasive tickeLife · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Bacterial endosymbionts of ticks are of interest due to their close evolutionary relationships with tick-vectored pathogens. For instance, whereas many ticks contain Francisella-like endosymbionts (FLEs), others transmit the mammalian pathogen Francisella tularensis. We recently sequenced the genome of an FLE present in the hard tick Amblyomma maculatum (FLE-Am) and showed that it likely evolved from a pathogenic ancestor. In order to expand our understanding of FLEs, in the current study we sequenced the genome of an FLE in the soft tick Ornithodoros moubata and compared it to the genomes of FLE-Am, Francisella persica-an FLE in the soft tick Argus (Persicargas) arboreus, Francisella sp. MA067296-a clinical isolate responsible for an opportunistic human infection, and F. tularensis, the established human pathogen. We determined that FLEs and MA067296 belonged to a sister taxon of mammalian pathogens, and contained inactivated versions of virulence genes present in F. tularensis, indicating that the most recent common ancestor shared by FLEs and F. tularensis was a potential mammalian pathogen. Our analyses also revealed that the two soft ticks (O. moubata and A. arboreus) probably acquired their FLEs separately, suggesting that the virulence attenuation observed in FLEs are not the consequence of a single acquisition event followed by speciation, but probably due to independent transitions of pathogenic francisellae into nonpathogenic FLEs within separate tick lineages. Additionally, we show that FLEs encode intact pathways for the production of several B vitamins and cofactors, denoting that they could function as nutrient-provisioning endosymbionts in ticks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.