Evidence map›Paper›PMID 29385074›Full record

ArticleNutrients2018

Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet.

Natália da Silva Lima, Lucimara Teixeira, Alessandra Gambero, Marcelo Lima Ribeiro

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Guarana (Paullinia cupana) as a potential tool for mesenchymal stromal cells priming in regenerative medicine.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  2. Review
  3. Review
  4. Article
  5. Fungal Endophytic Community Associated with Guarana (Journal of fungi (Basel, Switzerland) · 2020
    Article
  6. Article
  7. Remedying the Mitochondria to Cure Human Diseases by Natural Products.Oxidative medicine and cellular longevity · 2020
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Natália da Silva LimaLaboratory of Immunopharmacology and Molecular Biology, Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista-SP 12916-900, Brazil. lima.nat@gmail.com.ORCID 0000-0001-9448-4090
Lucimara TeixeiraLaboratory of Immunopharmacology and Molecular Biology, Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista-SP 12916-900, Brazil. lucimara.teixeira@usf.edu.br.
Alessandra GamberoLaboratory of Immunopharmacology and Molecular Biology, Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista-SP 12916-900, Brazil. alessandra.gambero@usf.edu.br.
Marcelo Lima RibeiroLaboratory of Immunopharmacology and Molecular Biology, Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista-SP 12916-900, Brazil. marcelo.ribeiro@usf.edu.br.ORCID 0000-0003-4529-7832
Universidade São Francisco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the effects of guarana on mitochondrial biogenesis in a high-fat diet (HFD)-fed mice. C57BL6J mice were divided in two groups: high-fat diet HFD and high-fat diet + guarana (HFD-GUA). Both groups received HFD and water ad libitum and the HFD-GUA group also received a daily gavage of guarana (1 g/kg weight). Body weight and food intake was measured weekly. Glycemic, triglyceride, and cholesterol levels were determined. VO₂ and energy expenditure (EE) were determined by indirect calorimetry. Gene expression was evaluated by real-time PCR and protein content by western blotting. The HFD-GUA group presented lower body weight, subcutaneous, retroperitoneal, visceral, and epididyimal adipose tissue depots, and glycemic and triglyceride levels, with no change in food intake and cholesterol levels. Furthermore, the HFD-GUA group presented an increase in VO₂ and basal energy expenditure (EE), as well as

Indexed as

Diet, High-FatOrganelle BiogenesisPaulliniaAdipose Tissue, BrownAMP-Activated Protein KinasesAnimalsAnti-Obesity AgentsCyclic AMP Response Element-Binding ProteinDisease Models, AnimalEnergy MetabolismMaleMice, Inbred C57BLMitochondria, MuscleMuscle, SkeletalNF-E2-Related Factor 1NF-E2-Related Factor 2AMP-Activated Protein KinasesAnti-Obesity AgentsCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinNfe2L1 protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 1NF-E2-Related Factor 2Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPlant ExtractsPpargc1a protein, mousePrkaa1 protein, mouseSirt1 protein, mouseSirtuin 1energy expenditureguarana (Paullinia cupana Kunth)mitochondrial biogenesisobesity

Identifiers

PMID29385074
PMCPMC5852741
OpenAlexW2794251337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.