ReviewDiagnostics (Basel, Switzerland)2018
Sensing Technologies for Detection of Acetone in Human Breath for Diabetes Diagnosis and Monitoring.
Review in Diagnostics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 265 citations in OpenAlex.
- Classification of Volatile Organic Compounds Using a Novel High-Frequency Quartz Crystal Microbalance Sensor Array Based on Ethyl Cellulose Microstructures.Sensors (Basel, Switzerland) · 2026Article
- Metal-organic frameworks for breath-based sensors: a review.Mikrochimica acta · 2026Review
- Skin acetone as a clinical diagnostic biomarker of ketosis.Nutrition & diabetes · 2026Article
- Local heating increases skin gas acetone content independent of systemic metabolism.Scientific reports · 2026Article
- Chitosan-poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)-AuNPs composite for acetone detection using plasmonic image sensor.Scientific reports · 2026Article
- Evolution of Biosensors and Current State-of-the-Art Applications in Diabetes Control.Biosensors · 2026Review
- Breathomics in Diabetes Management: A Noninvasive Approach for Precision Health Monitoring.Journal of diabetes research · 2026Review
- In Situ Growth of Lanthanide Coordination Polymers on Oxide Glass and Optical Fibers: A Promising Material for Chemical Sensing.ACS applied materials & interfaces · 2025Article
- Exhaled Aldehydes and Ketones as Biomarkers of Lung Cancer and Diabetes: Review of Sensor Technologies for Early Disease Diagnosis.Biosensors · 2025Review
- Recent progress of gas sensors toward olfactory display development.Nano convergence · 2025Review
- Review
- Steps toward clinical validation of exhaled volatile organic compound biomarkers for hypoglycemia in persons with type 1 diabetes.Scientific reports · 2025Article
- Enhanced Sensitivity in Photovoltaic 2D MoSSmall (Weinheim an der Bergstrasse, Germany) · 2024Article
- Diagnosis of Lung Cancer Through Exhaled Breath: A Comprehensive Study.Molecular diagnosis & therapy · 2024Article
- Review
- ZnO Hexagonal Nano- and Microplates Modified with Nanomaterials as a Gas-Sensitive Material for DMS Detection-Extended Studies.Sensors (Basel, Switzerland) · 2024Article
- Luminescence Probes in Bio-Applications: From Principle to Practice.Biosensors · 2024Review
- A solid state electrolyte based enzymatic acetone sensor.Scientific reports · 2024Article
- Innovations and applications of ketone body monitoring in diabetes care.Diabetology international · 2024Review
- Porosity Engineering of Dried Smart Poly(Biomacromolecules · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The review describes the technologies used in the field of breath analysis to diagnose and monitor diabetes mellitus. Currently the diagnosis and monitoring of blood glucose and ketone bodies that are used in clinical studies involve the use of blood tests. This method entails pricking fingers for a drop of blood and placing a drop on a sensitive area of a strip which is pre-inserted into an electronic reading instrument. Furthermore, it is painful, invasive and expensive, and can be unsafe if proper handling is not undertaken. Human breath analysis offers a non-invasive and rapid method for detecting various volatile organic compounds thatare indicators for different diseases. In patients with diabetes mellitus, the body produces excess amounts of ketones such as acetoacetate, beta-hydroxybutyrate and acetone. Acetone is exhaled during respiration. The production of acetone is a result of the body metabolising fats instead of glucose to produce energy. There are various techniques that are used to analyse exhaled breath including Gas Chromatography Mass Spectrometry (GC-MS), Proton Transfer Reaction Mass Spectrometry (PTR-MS), Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS), laser photoacoustic spectrometry and so on. All these techniques are not portable, therefore this review places emphasis on how nanotechnology, through semiconductor sensing nanomaterials, has the potential to help individuals living with diabetes mellitus monitor their disease with cheap and portable devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.