ArticleBiomacromolecules2018
Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications.
Article in Biomacromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Polymer-Grafted Nanoparticles as All-in-One Nanoplatforms.ACS polymers Au · 2026Review
- Sonochemical Functionalization of SiOMaterials (Basel, Switzerland) · 2025Article
- Organic nanoparticles with tunable size and rigidity by hyperbranching and cross-linking using microemulsion ATRP.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Advances of Cobalt Nanomaterials as Anti-Infection Agents, Drug Carriers, and Immunomodulators for Potential Infectious Disease Treatment.Pharmaceutics · 2022Review
- Hydrodynamic Characteristics and Conformational Parameters of Ferrocene-Terpyridine-Based Polymers.Polymers · 2022Article
- Biodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application.Biomaterials science · 2021Article
- Metallo-Polyelectrolytes: Correlating Macromolecular Architectures with Properties and Applications.Trends in chemistry · 2020Article
- The Use of Nanomedicine for Targeted Therapy against Bacterial Infections.Antibiotics (Basel, Switzerland) · 2019Review
- Crystallization-Driven Self-Assembly of Metallo-Polyelectrolyte Block Copolymers with a Polycaprolactone Core-Forming Segment.ACS macro letters · 2019Article
- Macromolecular-clustered facial amphiphilic antimicrobials.Nature communications · 2018Article
- Metallo-polyelectrolytes as a class of ionic macromolecules for functional materials.Nature communications · 2018Review
- Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates.Biomaterials · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Inappropriate and frequent use of antibiotics has led to the development of antibiotic-resistant bacteria, which cause infectious diseases that are difficult to treat. With the rising threat of antibiotic resistance, the need to develop effective new antimicrobial agents is prominent. We report antimicrobial metallopolymer nanoparticles, which were prepared by surface-initiated reversible addition-fragmentation chain transfer polymerization of a cobaltocenium-containing methacrylate monomer from silica nanoparticles. These particles are capable of forming a complex with β-lactam antibiotics, such as penicillin, rejuvenating the bactericidal activity of the antibiotic. Disk diffusion assays showed significantly increased antibacterial activities against both Gram-positive and Gram-negative bacteria. The improved efficiencies were attributed to the inhibition of hydrolysis of the β-lactam antibiotics and enhancement of local antibiotics concentration on a nanoparticle surface. In addition, hemolysis evaluations demonstrated minimal toxicity to red blood cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.