Evidence map›Paper›PMID 29384363›Full record

ArticleAnalytical chemistry2018

Isobaric Labeling of Intact Gangliosides toward Multiplexed LC-MS/MS-Based Quantitative Analysis.

Rodell C Barrientos, Qibin Zhang

Abstract read
In one paragraph

Article in Analytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rodell C BarrientosDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro , Greensboro, North Carolina 27412, United States.
Qibin ZhangDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro , Greensboro, North Carolina 27412, United States.ORCID 0000-0002-6135-8706
University of North Carolina at Greensboro · US

Funding

Protein Markers to Islet Autoimmunity and T1D ProgressionR01DK114345 · NIDDK · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI ZHANG, QIBIN · 2017 to 2022
$1.7M
Discovery and validation of biomarkers of cardiovascular complications in type 1 diabetesR01DK116731 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SNELL-BERGEON, JANET KATHLEEN, ZHANG, QIBIN · 2018 to 2020
$1.1M
An Ultrasensitive Mass Spectrometry Platform for Comprehensive Analysis of LipidsR21GM104678 · NIGMS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI TANG, KEQI, ZHANG, QIBIN · 2012 to 2014
$591k
NIDDK NIH HHS R01 DK114345NIDDK NIH HHS R01 DK116731NIGMS NIH HHS R21 GM104678
6 · The paper itself

Abstract

Gangliosides are sialic acid-containing glycosphingolipids recognized to play essential role in biological processes. Both the glycan and lipid structures influence their biological function and thus necessitate their determination as intact molecular species. To our knowledge, no multiplexed method for intact gangliosides currently exists. In this paper, we aimed to demonstrate an approach for isobaric labeling of intact gangliosides. Specifically, we carried out the rapid, chemoselective oxidation of sialic acid side chain in common ganglioside core structures using NaIO

Indexed as

Isotope LabelingChromatography, High Pressure LiquidGangliosidesMolecular StructureTandem Mass SpectrometryGangliosides

Identifiers

PMID29384363
PMCPMC6069520
OpenAlexW2786978844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.