Evidence map›Paper›PMID 29383885›Full record

ArticleActa physiologica (Oxford, England)2018

Increased FXYD1 and PGC-1α mRNA after blood flow-restricted running is related to fibre type-specific AMPK signalling and oxidative stress in human muscle.

D Christiansen, R M Murphy, J Bangsbo, C G Stathis, D J Bishop

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

D ChristiansenInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Vic., Australia.ORCID 0000-0001-8123-5087
R M MurphyDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic., Australia.
J BangsboDepartment of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen N, Denmark.
C G StathisInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Vic., Australia.
D J BishopInstitute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, Vic., Australia.
Victoria University · AUEdith Cowan University · AULa Trobe University · AUUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study explored the effects of blood flow restriction (BFR) on mRNA responses of PGC-1α (total, 1α1, and 1α4) and Na

methodsIn a randomized, crossover fashion, 8 healthy men (26 ± 5 year and 57.4 ± 6.3 mL kg

resultsMuscle hypoxia (assessed by near-infrared spectroscopy) was matched between BFR and HYP, which was higher than CON (~90% vs ~70%; P < .05). The mRNA levels of FXYD1 and PGC-1α isoforms (1α1 and 1α4) increased in BFR only (P < .05) and were associated with increases in indicators of oxidative stress and type I fibre ACC Ser

conclusionBlood flow restriction augmented exercise-induced increases in muscle FXYD1 and PGC-1α mRNA in men. This effect was related to increased oxidative stress and fibre type-dependent AMPK signalling, but unrelated to the severity of muscle hypoxia, lactate accumulation, and modulation of fibre type-specific CaMKII signalling.

Indexed as

AdultAMP-Activated Protein KinasesExerciseHumansMaleMembrane ProteinsMuscle, SkeletalOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphoproteinsProtein IsoformsRNA, MessengerRunningTranscription FactorsYoung AdultAMP-Activated Protein KinasesMembrane ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaphospholemmanPhosphoproteinsPPARGC1A protein, humanProtein IsoformsRNA, MessengerTranscription FactorsAMP-activated protein kinaseblood flow restrictionNa+-K+-ATPaseoxidative stressPGC-1αreactive oxygen species

Identifiers

PMID29383885
PMCPMC5969286
OpenAlexW2791135292

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.