Evidence map›Paper›PMID 29383798›Full record

ArticleCancer science2018

Reverse of non-small cell lung cancer drug resistance induced by cancer-associated fibroblasts via a paracrine pathway.

Quanhui Zhang, Junping Yang, Jie Bai, Jianzhuang Ren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

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  20. [Advancement of Cancer Associated Fibroblasts-derived Exosomes in Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Quanhui ZhangDepartment of Intervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID http://orcid.org/0000-0003-1358-3500
Junping YangDepartment of Dermatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jie BaiDepartment of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jianzhuang RenDepartment of Intervention, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment orchestrates the sustained growth, metastasis and recurrence of cancer. As an indispensable component of the tumor microenvironment, cancer-associated fibroblasts (CAF) are considered as an essential synthetic machine producing various tumor components, leading to cancer sustained stemness, drug resistance and tumor recurrence. Here, we developed a sustainable primary culture of lung cancer cells fed with lung cancer-associated fibroblasts, resulting in enrichment and acquisition of drug resistance in cancer cells. Moreover, IGF2/AKT/Sox2/ABCB1 signaling activation in cancer cells was observed in the presence of CAF, which induces upregulation of P-glycoprotein expression and the drug resistance of non-small cell lung cancer cells. Our results demonstrated that CAF cells constitute a mechanism for cancer drug resistance. Thus, traditional chemotherapy combined with insulin-like growth factor 2 (IGF2) signaling inhibitor may present an innovative therapeutic strategy for non-small cell lung cancer therapy.

Indexed as

A549 CellsAnimalsAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Cancer-Associated FibroblastsCarcinoma, Non-Small-Cell LungCell Line, TumorDrug Resistance, NeoplasmFemaleHumansInsulin-Like Growth Factor IILung NeoplasmsMiceMice, NudeNeoplasm Recurrence, LocalParacrine CommunicationAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Insulin-Like Growth Factor IIProto-Oncogene Proteins c-aktSOXB1 Transcription Factorscancer-associated fibroblastsdrug resistanceinsulin-like growth factor 2non-small cell lung cancerP-glycoprotein

Identifiers

PMID29383798
PMCPMC5891180
OpenAlexW2792983660

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.