Evidence map›Paper›PMID 29383687›Full record

ArticleMolecular neurobiology2018

Transcranial Ultrasound Stimulation Improves Long-Term Functional Outcomes and Protects Against Brain Damage in Traumatic Brain Injury.

Szu-Fu Chen, Wei-Shen Su, Chun-Hu Wu, Tsuo-Hung Lan, Feng-Yi Yang

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03896698 (Feasibility Study of Transcranial Ultrasound Stimulation on Alzheimer's Disease Patients), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03896698 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Feasibility Study of Transcranial Ultrasound Stimulation on Alzheimer's Disease Patients

TypeinterventionalSponsorNational Yang Ming Chiao Tung UniversityRan2019 to 2021Enrolled10ConditionsAlzheimer DiseaseArmsTranscranial Ultrasound Stimulation
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Photobiomodulation improves the frontal cognitive function of older adults.International journal of geriatric psychiatry · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Szu-Fu ChenDepartment of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan.
Wei-Shen SuDepartment of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Taipei, 11221, Taiwan.
Chun-Hu WuGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Tsuo-Hung LanDepartments of Psychiatry, National Yang-Ming University, Taipei, Taiwan.
Feng-Yi YangDepartment of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Taipei, 11221, Taiwan. fyyang@ym.edu.tw.ORCID http://orcid.org/0000-0003-0295-9242
National Yang Ming Chiao Tung University · TWCheng Hsin General Hospital · TWNational Defense Medical Center · TW

Funding

Cheng Hsin General Hospital Foundation CY10622 and CY10418Ministry of Science and Technology of Taiwan MOST 101-2314-B-350-001-MY3Ministry of Science and Technology of Taiwan MOST 104-2314-B-010-003-MY3Ministry of Science and Technology, Taiwan MOST 105-2221-E-010-003Veterans General Hospitals University System of Taiwan Joint Research Program VGHUST107-G7-6-1 and VGHUST106-G7-6-1
6 · The paper itself

Abstract

The purpose of this study was to assess the long-term treatment efficacy of low-intensity pulsed ultrasound (LIPUS) on functional outcomes, brain edema, and the possible involvement of reactions in mice following traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury received LIPUS treatment daily for a period of 4 weeks. The effects of LIPUS on edema were detected by MR imaging in the mouse brain at 148 days following TBI. Long-term functional outcomes of LIPUS stimulation were evaluated by behavioral analyses. One-way or two-way analysis of variance and Student's t test were used for statistical analyses, with a significant level of .05. Up to post-injury day 148, treatment with LIPUS significantly improved functional outcomes (all p < 0.05). LIPUS also significantly attenuated brain edema and neuronal death at day 148 after TBI (all p < 0.05). Furthermore, LIPUS reduced MMP9 activity, neutrophil infiltration, and microglial activation at day 1 or day 4 following TBI (all p < 0.05). Meanwhile, LIPUS increased the Bcl-2/Bax ratio and enhanced the phosphorylation of Bad and FOXO-1 at day 1 or day 4 following TBI (all p < 0.05). Almost 5 months of follow-up showed that the treatment efficacy of post-injury LIPUS stimulation on reduced brain edema and improved functional outcomes persisted over time after TBI. The neuroprotective effects of LIPUS are associated with a reduction of early inflammatory events and inhibition of apoptotic progression.

Indexed as

Ultrasonic WavesAnimalsApoptosisBrain-Derived Neurotrophic FactorBrain EdemaBrain Injuries, TraumaticMagnetic Resonance ImagingMaleMatrix Metalloproteinase 9Mice, Inbred C57BLNeuroprotective AgentsTreatment OutcomeBrain-Derived Neurotrophic FactorMatrix Metalloproteinase 9Neuroprotective AgentsApoptosisBrain edemaInflammationTraumatic brain injuryUltrasound

Identifiers

PMID29383687
OpenAlexW2786719884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.