ArticleBreast cancer research and treatment2018
The frequency of missed breast cancers in women participating in a high-risk MRI screening program.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Breast imaging with ultra-low field MRI.Scientific reports · 2026Article
- Challenges and implications of the use of artificial intelligence in health care, with an emphasis on nursing. Scoping review.Investigacion y educacion en enfermeria · 2025Article
- Early Detection of Breast Cancer in MRI Using AI.Academic radiology · 2025Article
- High-Temporal/High-Spatial Resolution Breast Magnetic Resonance Imaging Improves Diagnostic Accuracy Compared With Standard Breast Magnetic Resonance Imaging in Patients With High Background Parenchymal Enhancement.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Deep learning for predicting future lesion emergence in high-risk breast MRI screening: a feasibility study.European radiology experimental · 2023Article
- The utilization of artificial intelligence applications to improve breast cancer detection and prognosis.Saudi medical journal · 2023Review
- Missed Breast Cancers on MRI in High-Risk Patients: A Retrospective Case-Control Study.Tomography (Ann Arbor, Mich.) · 2022Article
- Evaluation of the Pink Luminous Breast LED-Based Technology Device as a Screening Tool for the Early Detection of Breast Abnormalities.Frontiers in medicine · 2021Article
- Breast Cancer Cell Detection and Characterization from Breast Milk-Derived Cells.Cancer research · 2020Article
- The supplemental value of mammographic screening over breast MRI alone in BRCA2 mutation carriers.Breast cancer research and treatment · 2020Article
- Differentiating benign and malignant mass and non-mass lesions in breast DCE-MRI using normalized frequency-based features.International journal of computer assisted radiology and surgery · 2020Article
- Redefining the sensitivity of screening mammography: A review.American journal of surgery · 2019Review
- Contrast-enhanced MRI for breast cancer screening.Journal of magnetic resonance imaging : JMRI · 2019Review
- The added value of mammography in different age-groups of women with and without BRCA mutation screened with breast MRI.Breast cancer research : BCR · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
purposeTo evaluate the frequency of missed cancers on breast MRI in women participating in a high-risk screening program.
methodsPatient files from women who participated in an increased risk mammography and MRI screening program (2003-2014) were coupled to the Dutch National Cancer Registry. For each cancer detected, we determined whether an MRI scan was available (0-24 months before cancer detection), which was reported to be negative. These negative MRI scans were in consensus re-evaluated by two dedicated breast radiologists, with knowledge of the cancer location. Cancers were scored as invisible, minimal sign, or visible. Additionally, BI-RADS scores, background parenchymal enhancement, and image quality (IQ; perfect, sufficient, bad) were determined. Results were stratified by detection mode (mammography, MRI, interval cancers, or cancers in prophylactic mastectomies) and patient characteristics (presence of BRCA mutation, age, menopausal state).
resultsNegative prior MRI scans were available for 131 breast cancers. Overall 31% of cancers were visible at the initially negative MRI scan and 34% of cancers showed a minimal sign. The presence of a BRCA mutation strongly reduced the likelihood of visible findings in the last negative MRI (19 vs. 46%, P < 0.001). Less than perfect IQ increased the likelihood of visible findings and minimal signs in the negative MRI (P = 0.021).
conclusionThis study shows that almost one-third of cancers detected in a high-risk screening program are already visible at the last negative MRI scan, and even more in women without BRCA mutations. Regular auditing and double reading for breast MRI screening is warranted.
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