Evidence map›Paper›PMID 29383618›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

Multiple brain metastases: a surgical series and neurosurgical perspective.

Maurizio Salvati, Maria Pia Tropeano, Vincenza Maiola, Laura Lavalle, Christian Brogna, Claudio Colonnese, Alessandro Frati, Alessandro D'Elia

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  13. Revisiting the Role of Surgical Resection for Brain Metastasis.Brain tumor research and treatment · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maurizio SalvatiDAI Neurology and Psychiatry, Department of Neurosurgery, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Maria Pia TropeanoDAI Neurology and Psychiatry, Department of Neurosurgery, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Vincenza MaiolaDAI Neurology and Psychiatry, Department of Neurosurgery, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Laura LavalleNeuroscience Department, University of Siena, Siena, Italy.
Christian BrognaClinical Fellow Neurosurgery, King's College Hospital, Greater London, London, UK.
Claudio ColonneseDAI Neurology and Psichiatry, Department of Neuroradiology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Alessandro FratiNeurosurgery Department, IRCCS NEUROMED INM, Neurochirurgia, Via Atinense, 18, 86077, Pozzilli, IS, Italy.
Alessandro D'EliaNeurosurgery Department, IRCCS NEUROMED INM, Neurochirurgia, Via Atinense, 18, 86077, Pozzilli, IS, Italy. deliaale@gmail.com.ORCID http://orcid.org/0000-0002-2070-8335

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite review papers claim for radical treatment of oligometastatic patients, only few surgical series have been published. In this study, we analyze results and actual role of surgical resection for the management of patients with multiple brain metastases. This retrospective study compares surgical results of two groups of patients consecutively treated in our Institute from January 2004 to June 2015. The first group comprises all 32 patients with multiple brain metastases with only 2-3 lesions who underwent surgical resection of all lesions; the second group comprises 30 patients with a single surgically treated brain mestastasis compatible with the first group (match-paired control series). Median survival was 14.6 months for patients with multiple brain metastases (range 1-28 months) and 17.4 months for patients with a single brain metastasis (range 4-38 months); the difference was not statistically significant (P = 0.2). Neurological condition improved in 59.4% of patients with multiple metastases, it remained unchanged in 37.5% and worsened in 3.1%. In our series, selected patients with only 2-3 lesions with well-controlled systemic disease, life expectancy of more than 3 months, Karnofsky's performance status > 60, and surgically accessible lesions, benefited from surgical treatment in terms of survival and quality of life, with reduction or disappearance of significant neurological deficits. The prognosis for these patients is similar to that of patients with a single metastasis. It seems that patients with breast cancer included in our series had the worst prognosis if compared to other histotypes.

Indexed as

Neurosurgical ProceduresAdultAgedAged, 80 and overBrain NeoplasmsBreast NeoplasmsCranial IrradiationFemaleHumansKarnofsky Performance StatusMaleMiddle AgedNeoplasm MetastasisPrognosisQuality of LifeRetrospective StudiesBrain metastasesNeurosurgeryOligometastasesRPA classesSurgery

Identifiers

PMID29383618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.