Evidence map›Paper›PMID 29383575›Full record

ArticleMycopathologia2018

Antifungal Susceptibility, Morphological and Molecular Characterization of Lasiodiplodia theobromae Isolated from a Patient with Keratitis.

Priscila Dallé da Rosa, Claudete Locatelli, Karla Scheid, Diane Marinho, Lúcia Kliemann, Alexandre Fuentefria, Luciano Zubaran Goldani

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. American journal of ophthalmology case reports · 2023
    Article
  4. Rhino sinusitis caused byMedical mycology case reports · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Priscila Dallé da RosaPrograma de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Claudete LocatelliServiço de Oftalmologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Karla ScheidServiço de Oftalmologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Diane MarinhoServiço de Oftalmologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Lúcia KliemannDepartamento de Patologia da Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Alexandre FuentefriaPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Luciano Zubaran GoldaniPrograma de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. lgoldani@ufrgs.br.
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lasiodiplodia theobromae is a rare ocular pathogen. We report a patient with fungal keratitis caused by L. theobromae. The patient was a 75-year-old male, a farmer with diabetes type II, and no previous history of ocular trauma. Histopathology analysis revealed the presence fungi invading Descemet's membrane of the cornea. The fungus was characterized by septate, highly bulged fungal filaments involving full corneal thickness in the corresponding histopathology specimens. A dematiaceous mold was isolated and initally identified as L. theobromae by microscopic and macroscopic morphology, and further confirmed by PCR-based determination of internal transcribed spacer (ITS) regions of ribosomal DNA. Antifungal susceptibility tests showed sensitivity to amphotericin B (AMB) and voriconazole ( VRC), and resistance to other azoles, including itraconazole (ITC) and fluconazole (FLC). Corneal transplant was performed. Despite in vitro itraconazole resistance, the patient was successfully treated with oral itraconazole, topical voriconazole and natamycin, combined with ocular injections of amphotericin B and voriconazole.

Indexed as

AgedAntifungal AgentsAscomycotaCorneaCorneal TransplantationDiabetes Mellitus, Type 2DNA, FungalDNA, Ribosomal SpacerDrug Resistance, FungalEye Infections, FungalHistocytochemistryHumansKeratitisMaleMicrobial Sensitivity TestsMicrobiological TechniquesAntifungal AgentsDNA, FungalDNA, Ribosomal SpacerAmphotericin BAntifungal treatmentCorneal ulcerFungal keratitisLasiodiplodia theobromaeVoriconazole

Identifiers

PMID29383575
OpenAlexW2791260288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.