ReviewCNS drugs2018
Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management.
Review in CNS drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- A systematic review of the prevalence of fatigue in common mental disorders (mood disorders, anxiety disorders, personality disorders, and trauma and stressor related disorders).BMC psychiatry · 2026Pooled it
- Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials.Journal of translational medicine · 2024Pooled it
- A Systematic Review and Individual Patient Data Network Analysis of the Residual Symptom Structure Following Cognitive-Behavioral Therapy and Escitalopram, Mirtazapine and Venlafaxine for Depression.Frontiers in psychiatry · 2022Pooled it
- Efficacy of Qigong Exercise for Treatment of Fatigue: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Exploring fatigue in clinically depressed adolescents: a secondary analysis of the IMPACT study sample.BMC psychology · 2026Trial
- The efficacy of integrated hepatitis C virus treatment in relieving fatigue in people who inject drugs: a randomized controlled trial.Substance abuse treatment, prevention, and policy · 2023Trial
- The Sentinel Sleep Theory: Unweaving the biological function of REM sleep.Sleep medicine: X · 2026Article
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- Errors or Adaptations? A Critical Review of Predictive Processing in Psychiatry.Behavioral sciences (Basel, Switzerland) · 2026Review
- Depression and anxiety symptom severity correlates with subjective fatigue characteristics in individuals with anxiety and mood disorders.BMC psychiatry · 2026Article
- Analysis of anticancer drug associated adverse reactions in depressive patients from vigibase.Scientific reports · 2025Article
- Changes in Depressive Patterns Before and After Lung Cancer Diagnosis: A Nationwide Population-Based Study.Psycho-oncology · 2025Article
- Long-term occupational outcomes in major depressive disorder: a 10-year follow-up study of symptom and comorbidity predictors.BMC psychiatry · 2025Article
- Fatigue as a central bridge: temporal dynamics between problematic smartphone use and depressive symptoms in Chinese adolescents.Child and adolescent psychiatry and mental health · 2025Article
- From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025Review
- Differential Fatigue Profile in Patients with Post-COVID Condition, Fibromyalgia, and Multiple Sclerosis.Journal of clinical medicine · 2025Article
- Prevalence of depressive symptoms and associated factors in Brazilian older adults: 2019 Brazilian National Health Survey.Cadernos de saude publica · 2025Article
- Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments.Frontiers in psychiatry · 2025Article
- Network characteristics of the youth's insomnia and emotional symptoms and their gender differences.Frontiers in psychiatry · 2025Article
- Recognising depression in non-human primates: a narrative review of reported signs of depression.PeerJ · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is a frequently reported symptom in major depressive disorder, occurring in over 90% of patients. Clinical presentations of fatigue within major depressive disorder encompass overlapping physical, cognitive and emotional aspects. While this review addresses the epidemiology, burden, functional impact and management of fatigue in major depressive disorder, the main focus is on available pharmacotherapy options and their comparative efficacies. Our review of the effects of pharmacological treatments on fatigue in major depressive disorder found that medications with dopaminergic and/or noradrenergic action such as modafinil, flupenthixol and atomoxetine were most effective in improving symptoms of fatigue and low energy. However, significant variation across studies in assessment tools and study inclusion/exclusion criteria may have contributed to inconsistent findings. The efficacy of non-pharmacological interventions is also discussed, including light therapy and exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.