ArticleEuropean radiology2018
Detection of early cartilage damage: feasibility and potential of gagCEST imaging at 7T.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis.Current rheumatology reports · 2024Review
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- Quantitative and Compositional MRI of the Articular Cartilage: A Narrative Review.Tomography (Ann Arbor, Mich.) · 2024Review
- MRI-based TSkeletal radiology · 2023Review
- Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.International journal of molecular sciences · 2022Article
- Novel Magnetic Resonance Imaging Tools for the Diagnosis of Degenerative Disc Disease: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Current and Future Advanced Imaging Modalities for the Diagnosis of Early Osteoarthritis of the Hip.Orthopedic research and reviews · 2022Review
- Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022Review
- Article
- The effect of viscosupplementation on early-stage knee osteoarthritis: Clinical evaluation and assessment of cartilage in vivo with 7 T MRI.Journal of clinical orthopaedics and trauma · 2021Article
- Can sodium MRI be used as a method for mapping of cartilage stiffness?Magma (New York, N.Y.) · 2021Article
- Detection of early cartilage degeneration in the tibiotalar joint using 3 T gagCEST imaging: a feasibility study.Magma (New York, N.Y.) · 2021Article
- In vivo biochemical assessment of cartilage with gagCEST MRI: Correlation with cartilage properties.NMR in biomedicine · 2021Article
- Musculoskeletal MR Imaging Applications at Ultra-High (7T) Field Strength.Magnetic resonance imaging clinics of North America · 2021Review
- Extracellular matrix at the muscle - tendon interface: functional roles, techniques to explore and implications for regenerative medicine.Connective tissue research · 2021Review
- Rapid volumetric gagCEST imaging of knee articular cartilage at 3 T: evaluation of improved dynamic range and an osteoarthritic population.NMR in biomedicine · 2020Article
- Morphological MRI of knee cartilage: repeatability and reproducibility of damage evaluation and correlation with gross pathology examination.European radiology · 2020Article
- Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI.NMR in biomedicine · 2019Article
- Functional MRI for evaluation of hyaline cartilage extracelullar matrix, a physiopathological-based approach.The British journal of radiology · 2019Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose was to implement a fast 3D glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) sequence at 7 T, test stability and reproducibility in cartilage in the knee in healthy volunteers, and evaluate clinical applicability in cartilage repair patients.
methodsExperiments were carried out on a 7-T scanner using a volume transmit coil and a 32-channel receiver wrap-around knee coil. The 3D gagCEST measurement had an acquisition time of 7 min. Signal stability and reproducibility of the GAG effect were assessed in eight healthy volunteers. Clinical applicability of the method was demonstrated in five patients before cartilage repair surgery.
resultsCoefficient of variation of the gagCEST signal was 1.9%. The reproducibility of the GAG effect measurements was good in the medial condyle (ICC = 0.87) and excellent in the lateral condyle (ICC = 0.97). GAG effect measurements in healthy cartilage ranged from 2.6%-12.4% compared with 1.3%-5.1% in damaged cartilage. Difference in GAG measurement between healthy cartilage and damaged cartilage was significant (p < 0.05).
conclusionsA fast 3D gagCEST sequence was applied at 7 T for use in cartilage in the knee, acquired within a clinically feasible scan time of 7 min. We demonstrated that the method has high stability, reproducibility and clinical applicability. KEY POINTS: • gagCEST measurements are stable and reproducible • A non-invasive GAG measurement with gagCEST can be acquired in 7 min • gagCEST is able to discriminate between healthy and damaged cartilage.
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