Evidence map›Paper›PMID 29383522›Full record

ArticleEuropean radiology2018

Staging liver fibrosis with DWI: is there an added value for diffusion kurtosis imaging?

Li Yang, Shengxiang Rao, Wentao Wang, Caizhong Chen, Ying Ding, Chun Yang, Robert Grimm, Xu Yan, Caixia Fu, Mengsu Zeng

Registry-linked trialAbstract read
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In one paragraph

Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06265272 (Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06265272 recruitingnot on this mapstarted 2023, after this paper: background citation

Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI

TypeobservationalSponsorMassachusetts General HospitalRan2023 to 2026Enrolled45ConditionsLiver Cirrhosis, Hepatic Cell Carcinoma, Portal HypertensionArmsInjection of a gadolinium contrast agen, Radiotracer Injection, Imaging
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. [Expert consensus on MRI diagnosis of liver fibrosis in chronic hepatitis B (version 2023)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Li YangDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Shengxiang RaoDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Wentao WangDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Caizhong ChenDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Ying DingDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Chun YangDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Robert GrimmMR Applications Predevelopment, Siemens Healthcare, Erlangen, Germany.
Xu YanMR Collaboration NE Asia, Siemens Healthcare, Shanghai, China.
Caixia FuSiemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China.
Mengsu ZengDepartment of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. zengmengsu@outlook.com.ORCID http://orcid.org/0000-0001-6054-0824

Funding

National Natural Science Foundation of China 81571661
6 · The paper itself

Abstract

objectivesTo assess liver fibrosis in patients with chronic liver disease using diffusion kurtosis imaging (DKI) in comparison with conventional diffusion-weighted imaging, with histology as reference standard.

methodsThis prospective study included 81 patients and DKI with b-values of 0, 200, 500, 1,000, 1,500, 2,000 s/mm

resultsThe MD (rho=-0.491, p<0.001), MK (rho=0.537, p<0.001) and ADC (rho=-0.496, p<0.001) correlated significantly with fibrosis stages, and ADC exhibited a strong negative correlation with MK (rho=-0.968; p<0.001) and a moderate association with MD (rho=0.601, p<0.001). Areas under the curves (AUCs) for predicting stage 2 fibrosis or greater were not significantly different (p>0.05) between MK (0.809) and ADC (0.797) as well as between MD (0.715) and ADC. AUCs were also similar for MD (0.710), MK (0.768) and ADC (0.747) for predicting stage 3 fibrosis or greater.

conclusionAlthough DKI is feasible for predicting liver fibrosis in patients with chronic liver disease, MD and MK offer similar diagnostic performance to ADC values. KEY POINTS: • Diffusion kurtosis imaging is feasible for staging liver fibrosis. • Diffusion kurtosis and monoexponential model are highly correlated. • The kurtosis model offers no added value to the conventional, monoexponential model.

Indexed as

AdultAgedDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedLiver CirrhosisMaleMiddle AgedObserver VariationProspective StudiesSensitivity and SpecificitySeverity of Illness IndexDiagnostic imagingDiffusion-weighted MRILiver diseaseLiver fibrosisMagnetic resonance imaging

Identifiers

PMID29383522

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.