ArticleClinical research in cardiology : official journal of the German Cardiac Society2018
Impact of generalized anxiety disorder (GAD) on prehospital delay of acute myocardial infarction patients. Findings from the multicenter MEDEA study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression: systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Pooled it
- Review
- Factors associated with prehospital delay in acute myocardial infarction in Maldives.International journal of emergency medicine · 2023Article
- Underestimated prognostic value of depression in patients with obstructive coronary artery disease.Frontiers in cardiovascular medicine · 2022Article
- Surviving to Acute Myocardial Infarction: The Role of Psychological Factors and Alexithymia in Delayed Time to Searching Care: A Systematic Review.Journal of clinical medicine · 2021Review
- Midregional pro atrial natriuretic peptide: a novel important biomarker for noise annoyance-induced cardiovascular morbidity and mortality?Clinical research in cardiology : official journal of the German Cardiac Society · 2021Observational
- The impact of the Type D Personality pattern on prehospital delay in patients suffering from acute myocardial infarction.Journal of thoracic disease · 2020Article
- Predictors of transportation delay in patients with suspected ST-elevation-myocardial infarction in the VIENNA-STEMI network.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- FIFA World Cup 2018: effect of emotional stress on conventional heart rate variability metrics.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Polyhedral erythrocytes in intracoronary thrombus and their association with reperfusion in myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- The MEDEA FAR-EAST Study: Conceptual framework, methods and first findings of a multicenter cross-sectional observational study.BMC emergency medicine · 2019Observational
- Threat-related disorders as persistent motivational states of defense.Current opinion in behavioral sciences · 2019Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAnxiety has been identified as a cardiac risk factor. However, less is known about the impact of generalized anxiety disorder (GAD) on prehospital delay during an acute myocardial infarction (AMI). This study assessed the impact of GAD on prehospital delay and delay related cognition and behavior.
methodsData were from the cross-sectional Munich examination of delay in patients experiencing acute myocardial infarction (MEDEA) study with a total of 619 ST-elevated myocardial infarction (STEMI) patients. Data on socio-demographic, clinical and psycho-behavioral characteristics were collected at bedside. The outcome was assessed with the Generalized Anxiety Disorder scale (GAD-7). A GAD-7 score greater than or equal to 10 indicates general anxiety disorder.
resultsA total of 11.47% (n = 71) MI patients suffered from GAD. GAD was associated with decreased odds of delay compared to patients without GAD (OR 0.58, 95% CI 0.35-0.96), which was more significant in women (112 vs. 238 min, p = 0.02) than in men (150 vs. 198 min, p = 0.38). GAD was highly correlated with acute anxiety (p = 0.004) and fear of death (p = 0.005). Nevertheless, the effect remained significant after controlling for these two covariates. GAD patients were more likely to perceive a higher cardiovascular risk (OR 2.56, 95% CI 1.37-4.76) in 6 months before MI, which leads to the higher likelihood of making self-decision to go to the hospital (OR 2.68, 95% CI 1.48-4.85) in the acute phase. However, GAD was also highly associated with impaired psychological well-being, stress and fatigue (p < 0.0001).
conclusionsIn AMI patients, GAD was independently associated with less prehospital delay, but led to an impaired psychological state.
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