ArticleNeuroradiology2018
Volumetric assessment of tumor size changes in pediatric low-grade gliomas: feasibility and comparison with linear measurements.
Article in Neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment ofAJNR. American journal of neuroradiology · 2024Trial
- Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- Tumor Response Assessment in Diffuse Intrinsic Pontine Glioma: Comparison of Semiautomated Volumetric, Semiautomated Linear, and Manual Linear Tumor Measurement Strategies.AJNR. American journal of neuroradiology · 2020Trial
- Article
- The use of minor response, volumetric assessment, and growth rate kinetics as endpoints in grade 1-3 glioma clinical trials: a RANO perspective.Neuro-oncology · 2025Review
- The relationship between imaging features, therapeutic response, and overall survival in pediatric diffuse intrinsic pontine glioma.Neurosurgical review · 2024Article
- Basics for Pediatric Brain Tumor Imaging: Techniques and Protocol Recommendations.Brain tumor research and treatment · 2024Review
- Intraoperative MRI Assessment of the Tissue Damage during Laser Ablation of Hypothalamic Hamartoma.Diagnostics (Basel, Switzerland) · 2023Article
- Evaluation of RANO Criteria for the Assessment of Tumor Progression for Lower-Grade Gliomas.Cancers · 2023Article
- Towards an Automated Approach to the Semi-Quantification of [Journal of clinical medicine · 2023Article
- Standardized brain tumor imaging protocols for clinical trials: current recommendations and tips for integration.Frontiers in radiology · 2023Review
- Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas.Acta neuropathologica communications · 2022Article
- Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry.Neuro-oncology · 2022Article
- Clinical and molecular characteristics of pediatric low-grade glioma complicated with ventriculo-peritoneal shunt related ascites.Journal of neuro-oncology · 2022Article
- Development and Practical Implementation of a Deep Learning-Based Pipeline for Automated Pre- and Postoperative Glioma Segmentation.AJNR. American journal of neuroradiology · 2022Article
- Current concepts in radiologic assessment of pediatric brain tumors during treatment, part 1.Pediatric radiology · 2018Review
- Integrated response analysis of pediatric low-grade gliomas during and after targeted therapy treatment.Neuro-oncology advancesArticle
- Comparison of volumetric and 2D-based response methods in the PNOC-001 pediatric low-grade glioma clinical trial.Neuro-oncology advancesArticle
- Evolution and implementation of radiographic response criteria in neuro-oncology.Neuro-oncology advancesReview
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe report a retrospective comparison between bi-dimensional RANO criteria and manual volumetric segmentation (MVS) in pediatric low-grade gliomas.
methodsMRI FLAIR or T1 post contrast images were used for assessment of tumor response. Seventy patients were included in this single center study, for each patient two scans were assessed ("time 0" and "end of therapy") and response to therapy was evaluated for both methods. Inter-reader variability and average time for volumetric assessment were also calculated.
resultsFourteen (20%) of the 70 patients had discordant results in terms of response assessment between the bi-dimensional measurements and MVS. All volumetric response assessments were in keeping with the subjective analysis of tumor (radiology report). Of the 14 patients, 6 had stable disease (SD) on MVS and progressive disease (PD) on 2D assessment, 5 patients had SD on MVS and partial response (PR) on 2D assessment, 2 patients had PD on MVS and SD on 2D assessment, and 1 patient had PR on MVS and SD on 2D analysis. The number of discordant results rises to 21(30%) if minor response is integrated in the response assessment. MVS was relatively fast and showed high inter-reader concordance.
conclusionOur analysis shows that therapeutic response classification may change in a significant number of children by performing a volumetric tumor assessment. Furthermore, MVS is not particularly time consuming and has very good inter-reader concordance.
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