ArticleWorld journal of surgery2018
Cervical Lymph Node Metastases of Papillary Thyroid Carcinoma, in the Central and Lateral Compartments, in Children and Adolescents: Predictive Factors.
Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma.European thyroid journal · 2022Guideline
- Paediatric differentiated thyroid carcinoma: a UK National Clinical Practice Consensus Guideline.Endocrine-related cancer · 2022Guideline
- Extrathyroidal extension is independently associated with cervical lymph node metastasis in pediatric papillary thyroid carcinoma.Archives of endocrinology and metabolism · 2026Article
- Risk factors for lung metastasis in children and adolescent patients with papillary thyroid cancer: A retrospective cohort study.Endocrine · 2026Article
- Risk factor analysis of childhood and adolescent thyroid cancer mediastinal lymph node and distant metastasis.Frontiers in oncology · 2025Article
- Thyroid surgery in children: a single-center experience of 20 years.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Risk factors associated with preferential lateral lymph node metastasis in papillary thyroid carcinoma.Cancer medicine · 2023Article
- Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer.Cells · 2022Article
- Increased trend of thyroid cancer in childhood over the last 30 years in EU countries: a call for the pediatric surgeon.European journal of pediatrics · 2022Observational
- Analysis of risk factors for lateral lymph node metastasis in papillary thyroid carcinoma: A retrospective cohort study.World journal of otorhinolaryngology - head and neck surgery · 2022Article
- The localization of thyroid cancers on the thyroid gland is a new risk factor for metastases of perithyroidal, peritracheal and central lymph nodes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Factors Influencing Cervical Lymph Node Metastasis in Pediatric Differentiated Thyroid Cancers.Indian journal of surgical oncology · 2022Article
- Clinical study of ultrasonic evaluation of T/N staging of differentiated thyroid carcinoma using AJCC 8th staging criteria.PloS one · 2022Article
- Predictive Factors Affecting the Development of Central Lymph Node Metastasis in Papillary Thyroid Cancer.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Review
- Article
- Familial Non-Medullary Thyroid Carcinoma in Pediatric Age: Our Surgical Experience.World journal of surgery · 2021Article
- Clinical Heterogeneity of Differentiated Thyroid Cancer between Children Less than 10 Years of Age and Those Older than 10 Years: A Retrospective Study of 70 Cases.European thyroid journal · 2021Article
- Correlation between sonographic features and pathological findings of cervical lymph node metastasis of differentiated thyroid carcinoma.Gland surgery · 2021Article
- Utility of sonography for identifying metastatic cervical adenopathy in children with differentiated thyroid carcinoma at presentation.Pediatric radiology · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problem statementThe aim of our study was to identify predictive factors for lymph node metastases (LNM) in children and adolescents with papillary thyroid carcinoma (PTC) and their impact on survival.
methodsThe authors conducted an Italian multicentric retrospective analysis on 132 pediatric patients (0-18 years old) affected by PTC between 2000 and 2014. The investigated variables were demographic characteristics of the patients, clinicopathological features of PTCs, and persistence/recurrence of disease. The female/male ratio was 3.1:1. The median age was 14.3 ± 3.5 years (range 4-18 years). Total thyroidectomy was performed in all the patients, followed by lymph node dissection in 87 patients (65.9%). Metastatic lymph node involvement was confirmed in 73 patients (55.3%): lateral compartment (LC) in 25 patients (34.2%), central compartment (CC) in 17 patients (23.3%), and both compartments in 31 patients (42.5%).
resultsMultifocality (P < .00), vascular invasion (P = .04), infiltration of the thyroid capsule (P < .00), minimal extrathyroidal extension (P < .00), diffuse sclerosing variant of PTC (P = .02), and presence of LNM in the LC (P < .00) were significantly associated with LNM in CC. Infiltration of the thyroid capsule (P < .00), massive extrathyroidal extension (P = .03), distant metastases (P = .02), PTC, not otherwise specified (P < .00), and presence of LNM in the CC (P < .00) were significantly associated with LNM in LC. Age, sex and size of PTC were not correlated with the presence of cervical LNM. Moreover, presence of LNM in CC increases the risk of persistence (P < .01) and recurrence (P < .02) of PTC in children and adolescents.
conclusionsMost predictors, unfortunately, are only identified post-operatively by histopathologic examination: Just a small part of them can be pre-operatively detected with a low-sensitivity neck ultrasonography. In PTC patients with pre-operative predictors, we suggest an accurate pre- and intra-operative evaluation of CC and/or LC to find suspicious lymph nodes. The presence of LNM in CC has an impact on disease/progression/relapse-free survival. We suggest performing RAI therapy and an accurate follow-up for pediatric patients with only post-operative predictors.
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