Evidence map›Paper›PMID 29383410›Full record

ReviewDer Nervenarzt2018

[Pharmacogenetics in psychiatry: state of the art].

D J Müller, E J Brandl, F Degenhardt, K Domschke, H Grabe, O Gruber, J Hebebrand, W Maier, A Menke, M Riemenschneider and 7 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Nervenarzt, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. The role of genetics and genomics in clinical psychiatry.Dialogues in clinical neuroscience · 2018
    Review
  7. No Effect of Dose Adjustment to theFrontiers in psychiatry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

D J MüllerCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College St., R132, Toronto, ON, M5T 1R8, Kanada. daniel.mueller@camh.ca.
E J BrandlKlinik für Psychiatrie und Psychotherapie, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Deutschland.
F DegenhardtInstitut für Humangenetik, Universitätsklinikum Bonn, Bonn, Deutschland.
K DomschkeKlinik für Psychiatrie und Psychotherapie, Universität Freiburg, Freiburg, Deutschland.
H GrabeKlinik und Poliklinik für Psychiatrie und Psychotherapie an der Universitätsmedizin Greifswald, Universität Greifswald, Greifswald, Deutschland.
O GruberKlinik für Allgemeine Psychiatrie, Zentrum für Psychosoziale Medizin, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
J HebebrandKlinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
W MaierKlinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn, Bonn, Deutschland.
A MenkeKlinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Zentrum für Psychische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Deutschland.
M RiemenschneiderKlinik für Psychiatrie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.
M RietschelZentralinstitut für Seelische Gesundheit, Mannheim, Deutschland.
D RujescuKlinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin-Luther-Universität Halle-Wittenberg, Halle, Deutschland.
T G SchulzeInstitut für Psychiatrische Phänomik und Genomik (IPPG), Klinikum der Universität München, LMU München, München, Deutschland.
L Tebartz van ElstKlinik für Psychiatrie und Psychotherapie, Universität Freiburg, Freiburg, Deutschland.
O TüscherKlinik für Psychiatrie und Psychotherapie, Universitätsmedizin der Johannes-Gutenberg Universität, Mainz, Deutschland.
J DeckertKlinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Zentrum für Psychische Gesundheit, Universitätsklinikum Würzburg, Würzburg, Deutschland.
das DGPPN Referat Neurobiologie und Genetik
University Hospital Bonn · DECentre for Addiction and Mental Health · CAHeidelberg University · DEJohannes Gutenberg University Mainz · DEUniversitätsklinikum des Saarlandes · DECentral Institute of Mental Health · DELMU Klinikum · DEUniversitätsklinikum Würzburg · DEUniversitätsmedizin Greifswald · DEUniversity Medical Center Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, the current literature on pharmacogenetics of antidepressants, antipsychotics and lithium are summarized by the section of Neurobiology and Genetics of the German Society of Psychiatry, Psychotherapy and Neurology (DGPPN). The publications of international expert groups and regulatory authorities are reviewed and discussed. In Germany, a statement on pharmacogenetics was also made by the gene diagnostics committee of the Ministry of Health. The DGPPN supports two recommendations: 1) to perform CYP2D6 genetic testing prior to prescription of tricyclic antidepressants and 2) to determine the HLA-B*1502 genotype in patients of Asian origin before using carbamazepine. The main obstacle for a broad application of pharmacogenetic tests in psychiatry remains the lack of large prospective studies, for both single gene-drug pair and cobinatorial pharmacogenetic tests, to evaluate the benefits of genetic testing. Psychiatrists, geneticists and funding agencies are encouraged to increase their efforts for the future benefit of psychiatric patients.

Indexed as

Antidepressive AgentsAntidepressive Agents, TricyclicAntipsychotic AgentsAsian PeopleATP Binding Cassette Transporter, Subfamily BBipolar DisorderCarbamazepineCytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6Depressive DisorderForecastingGenetic VariationGenotypeHLA-B15 AntigenHumansLithium CompoundsABCB1 protein, humanAntidepressive AgentsAntidepressive Agents, TricyclicAntipsychotic AgentsATP Binding Cassette Transporter, Subfamily BCarbamazepineCYP2C19 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2D6HLA-B*15:02 antigenHLA-B15 AntigenLithium CompoundsAntidepressantsAntipsychoticsLithiumPersonalised medicinePharmacokinetics

Identifiers

PMID29383410
OpenAlexW2791191356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.