Evidence map›Paper›PMID 29383333›Full record

ArticleJournal of the Endocrine Society2018

Embryonic Exposure to Dexamethasone Affects Nonneuronal Cells in the Adult Paraventricular Nucleus of the Hypothalamus.

Krystle A Frahm, Robert J Handa, Stuart A Tobet

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Impacts of prenatal resiquimod exposure during late gestation on rat offspring development and behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
  13. Review
  14. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Krystle A FrahmDepartment of Biomedical Sciences and School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523.
Robert J HandaDepartment of Biomedical Sciences and School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523.
Stuart A TobetDepartment of Biomedical Sciences and School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523.
Colorado State University · US

Funding

Sex-Specific Programming of the HPA Axis by GlucocorticoidsP50MH082679 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M · 2007 to 2011
$5.9M
Estrogen Regulation of the Hypothalamo-Pituitary-Adrenal AxisR01DK105826 · NIDDK · COLORADO STATE UNIVERSITY · PI MYERS, BRENT PHILIP · 2015 to 2020
$2.1M
Increased Prenatal Glucocorticoids on Vascularization in the Paraventricular NuclF31HD074496 · NICHD · COLORADO STATE UNIVERSITY · PI FRAHM, KRYSTLE ANNE · 2013 to 2013
$27k
NICHD NIH HHS F31 HD074496NIDDK NIH HHS R01 DK105826NIMH NIH HHS P50 MH082679
6 · The paper itself

Abstract

Neurons in the paraventricular nucleus of the hypothalamus (PVN) integrate peripheral signals and coordinate responses that maintain numerous homeostatic functions. An excess of glucocorticoids during fetal development results in long-lasting consequences tied to disrupted PVN development. The PVN contains a distinct neuronal population and a threefold greater vascular density than the surrounding brain regions that prepubertally is reduced in offspring exposed to excess glucocorticoids

Indexed as

astrocytesglucocorticoidsHPA-axisparaventricular nucleus of the hypothalamuspericytes

Identifiers

PMID29383333
PMCPMC5789044
OpenAlexW2776605722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.