ArticleWellcome open research2017
Children's Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.
Open access · goldAbstract read
In one paragraph
Article in Wellcome open research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023Pooled it
- Early weaning from oxygen therapy in African children with severe pneumonia.BMC medicine · 2025Trial
- Effect of nutritional supplementation with lipid-based therapeutic food on body composition of non-severely malnourished African children aged 6-59 months hospitalized with severe pneumonia.Journal of tropical pediatrics · 2025Trial
- Trial
- Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial.Intensive care medicine · 2018Trial
- A cost-consequence analysis of the children's administration oxygenation strategies trial (COAST) in severe pneumonia.PLOS global public health · 2026Article
- Bridging the Gap: The Challenge of Conducting Clinical Trials in Sub-Saharan Africa.Anesthesia and analgesia · 2025Article
- Characteristics and outcomes of children initiated on high flow nasal cannula and continuous positive airway pressure at the emergency centre of a district hospital in South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025Article
- Hydroxyurea - Pragmatic Reduction In Mortality and Economic burden (H-PRIME): A 2x2x2 factorial randomised open-label trial investigating practical approaches to the treatment of sickle cell disease at four sites in Eastern Uganda.Wellcome open research · 2025Article
- Swallowing and feeding of young children on high-flow oxygen therapy.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2024Article
- A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial).Wellcome open research · 2024Article
- Cardiovascular abnormalities in chest radiographs of children with pneumonia, Uganda.Bulletin of the World Health Organization · 2023Article
- Implication of the 2014 World Health Organization Integrated Management of Childhood Illness Pneumonia Guidelines with and without pulse oximetry use in Malawi: A retrospective cohort study.Gates open research · 2023Article
- Challenges and Solutions in translating sepsis guidelines into practice in resource-limited settings.Translational pediatrics · 2021Review
- Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study.BMJ open · 2021Article
- Estimated Cost-effectiveness of Solar-Powered Oxygen Delivery for Pneumonia in Young Children in Low-Resource Settings.JAMA network open · 2021Article
- Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.Wellcome open research · 2021Article
- Common bacteria in sputum or gastric lavage of patients presenting with signs and symptoms of lower respiratory tract infections.The Pan African medical journal · 2021Article
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
- Nasal high flow therapy introduction lowers reintubation risk in a Peruvian paediatric intensive care unit.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 4 countries.
Kathryn MaitlandDepartment of Paediatrics, Faculty of Medicine, Imperial College London, London, W2 1PG, UK.ORCID https://orcid.org/0000-0002-0007-0645
Sarah KiguliDepartment of Paediatrics, Mulago Hospital, Makerere College of Health Sciences, Kampala, Uganda.
Robert O OpokaDepartment of Paediatrics, Mulago Hospital, Makerere College of Health Sciences, Kampala, Uganda.
Peter Olupot-OlupotMbale Clinical Research Institute, Mbale, Uganda.
Charles EngoruDepartment of Paediatrics, Soroti Regional Referral Hospital, Soroti, Uganda.
Patricia NjugunaKilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, Kilifi, UK.
Victor BandikaDepartment of Paediatrics, Coast Provincial General Hospital, Mombasa, Kenya.
Ayub MpoyaKilifi Clinical Trials Facility, KEMRI-Wellcome Trust Research Programme, Kilifi, UK.
Andrew BushDepartment of Paediatrics, Faculty of Medicine, Imperial College London, London, W2 1PG, UK.
Thomas N WilliamsDepartment of Paediatrics, Faculty of Medicine, Imperial College London, London, W2 1PG, UK.ORCID https://orcid.org/0000-0003-4456-2382
Richard GrieveDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, WC1H 9SH, UK.
Zia SadiqueDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, WC1H 9SH, UK.
John FraserThe Critical Care Research Group, University of Queensland The Prince Charles Hospital and St Andrews Hospital, Clinical Science Building Rode Road, Chermside, QLD, 4032, Australia.
David HarrisonIntensive Care National Audit & Research Centre (ICNARC), London, WC1V 6AZ, UK.
Kathy RowanIntensive Care National Audit & Research Centre (ICNARC), London, WC1V 6AZ, UK.
Royal Free London NHS Foundation Trust · GBIntensive Care National Audit & Research Centre · GBLondon School of Hygiene & Tropical Medicine · GBMulago Hospital · UGMbale Hospital · UGRoyal Brompton & Harefield NHS Foundation Trust · GBSoroti Hospital · UGThe University of Queensland · AU
Funding
Medical Research Council G0601027Medical Research Council MR/L004364/1
Abstract
PubMed holds no abstract for this paper.
Indexed as
AfricaAirVO2 High flow oxygenChildrenEmergency Care Hypoxia Pneumonia Randomised controlled trialPermissive hypoxia
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.