ArticleConservation physiology2017
Body water conservation through selective brain cooling by the carotid rete: a physiological feature for surviving climate change?
Article in Conservation physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Estimating the Impacts of Future Extreme Heat on Dryland Threatened Mammals: An Australian Case Study.Global change biology · 2026Pooled it
- Revised concept of rete-like collateral formation:Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Review
- Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.bioRxiv : the preprint server for biology · 2026Article
- Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation.Acta physiologica (Oxford, England) · 2025Review
- Revisiting concepts of thermal physiology: understanding negative feedback and set-point in mammals, birds, and lizards.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Can thermoregulatory response to heat stress be improved in lactating dairy cows? Insights from counter-current heat transfer systems impacting reproduction.The Journal of reproduction and development · 2025Article
- Association of Environmental Temperature and Relative Humidity with Ocular and Flank Temperatures in Dromedary Camels.Animals : an open access journal from MDPI · 2025Article
- Fascinating wonderful network: Rete mirabile of the maxillary artery in cats - minireview.Veterinary research communications · 2024Review
- A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation.European journal of applied physiology · 2023Review
- Arterial Blood Supply to the Cerebral Arterial Circle in the Selected Species of Carnivora Order from Poland.Animals : an open access journal from MDPI · 2023Article
- The rete mirabile: a possible control site for swimbladder function.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Comparison of the Rostral Epidural Rete Mirabile and the Patterns of Its Blood Supply in Selected Suiformes and Hippopotamuses.Animals : an open access journal from MDPI · 2023Article
- Selective Brain Cooling: A New Horizon of Neuroprotection.Frontiers in neurology · 2022Review
- Ultradian oscillations in brain temperature in sheep: implications for thermoregulatory control?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- High-Resolution Computed Tomography Imaging of the Cranial Arterial System and Rete Mirabile of the Cat (Felis catus).Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Large herbivore assemblages in a changing climate: incorporating water dependence and thermoregulation.Ecology letters · 2019Article
- How does homeostasis happen? Integrative physiological, systems biological, and evolutionary perspectives.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Conserving diggers: from gold miners to aardvarks.Conservation physiology · 2018Article
- Selection of preclinical models to evaluate intranasal brain cooling for acute ischemic stroke.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some mammals have the ability to lower their hypothalamic temperature below that of carotid arterial blood temperature, a process termed selective brain cooling. Although the requisite anatomical structure that facilitates this physiological process, the carotid rete, is present in members of the Cetartiodactyla, Felidae and Canidae, the carotid rete is particularly well developed in the artiodactyls, e.g. antelopes, cattle, sheep and goats. First described in the domestic cat, the seemingly obvious function initially attributed to selective brain cooling was that of protecting the brain from thermal damage. However, hyperthermia is not a prerequisite for selective brain cooling, and selective brain cooling can be exhibited at all times of the day, even when carotid arterial blood temperature is relatively low. More recently, it has been shown that selective brain cooling functions primarily as a water-conservation mechanism, allowing artiodactyls to save more than half of their daily water requirements. Here, we argue that the evolutionary success of the artiodactyls may, in part, be attributed to the evolution of the carotid rete and the resulting ability to conserve body water during past environmental conditions, and we suggest that this group of mammals may therefore have a selective advantage in the hotter and drier conditions associated with current anthropogenic climate change. A better understanding of how selective brain cooling provides physiological plasticity to mammals in changing environments will improve our ability to predict their responses and to implement appropriate conservation measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.