Evidence map›Paper›PMID 29383164›Full record

ArticleOncotarget2017

Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway.

Yanping Yang, Jieqiong Zhao, Juan Zhang, Yonghong Lei, Fang Yuan, Lu Liu, Haibo Gao, Hua Guo, Xiaolin Niu, Ruirui Chen and 8 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Yanping Yang *Cardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Jieqiong Zhao *Cardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Juan Zhang *Cardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Yonghong LeiWound Healing and Cell Biology Laboratory, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100853, PR China.
Fang YuanDepartment of Orthopedics, Chinese PLA General Hospital, Beijing 100853, PR China.
Lu LiuDepartment of Nutrition, Chinese PLA General Hospital, Beijing 100853, PR China.
Haibo GaoCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Hua GuoCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Xiaolin NiuCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Ruirui ChenCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Xiaobing FuWound Healing and Cell Biology Laboratory, The First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100853, PR China.
Yan HanDepartment of Plastic Surgery, Chinese General Hospital, Beijing 100853, PR China.
Hua HanDepartment of Molecular Biology, The Fourth Military Medical University, Xian 710038, PR China.
Tung ChanCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Lianyou ZhaoCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Haichang WangCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Qiangsun ZhengCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Xue LiCardiovascular Department, Tangdu Hospital, The Fourth Military Medical University, Xian 710038, PR China.
Air Force Medical University · CNChinese PLA General Hospital · CNFirst Affiliated Hospital of Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of the AKT2/NBA1/SPK1 signaling cascade in macrophage migration regulation and post-ischemic cardiac remodeling was investigated. We determined that the AKT2/NBA1/SPK1 signaling cascade regulated macrophage migration. A novel role for NBA1 in macrophage migration was discovered. Elevated AKT2 phosphorylation, NBA1, SPK1 (along with phosphorylated SPK1) levels, macrophage recruitment, apoptosis, and fibrosis were found within the infarct area. Atorvastatin had a beneficial effect on cardiac remodeling following myocardial infarction by inhibiting AKT2/NBA1/SPK1-mediated macrophage recruitment, apoptosis, and collagen deposition while increasing angiogenesis in the infarct area. Atorvastatin-related protection of cardiac remodeling following myocardial infarction was abolished in SPK1-KO mice. The AKT2/NAB1/SPK1 pathway is a novel regulating factor of macrophage migration and cardiac remodeling after myocardial infarction.

Indexed as

atorvastatincardiac functionmacrophage migrationmyocardial infarction

Identifiers

PMID29383164
PMCPMC5777776
OpenAlexW2773880661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.