ArticleOncotarget2017
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Association between extreme heat exposure and risk of preterm birth and its effect modifiers: a systematic review and meta-analysis.Journal of exposure science & environmental epidemiology · 2026Article
- Short-term exposure to ambient air pollution and emergency ambulance dispatches for precipitous labor: a time-series study in Guangzhou, China.Scientific reports · 2026Article
- Alterations of Growth Performance, Blood Parameters, and Antioxidant Function of Brown Adipose Tissue in Mice Exposed to Cold.Antioxidants (Basel, Switzerland) · 2026Article
- Effect of non-optimal ambient temperature on preterm birth and its heterogeneity in various social sub-groups: a report from the Indo Gangetic Plains of India.BMC pregnancy and childbirth · 2026Article
- Article
- Impact of early life exposure to heat and cold on linguistic development in two-year-old children: findings from the ELFE cohort study.Environmental health : a global access science source · 2025Article
- Integrated mRNA and miRNA analysis reveals the regulatory network of oxidative stress and inflammation in Coilia nasus brains during air exposure and salinity mitigation.BMC genomics · 2024Article
- Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development.International journal of molecular sciences · 2024Article
- Fetal CCL2 signaling mediates offspring social behavior and recapitulates effects of prenatal stress.Brain, behavior, and immunity · 2024Article
- Melatonin Supplementation during the Late Gestational Stage Enhances Reproductive Performance of Sows by Regulating Fluid Shear Stress and Improving Placental Antioxidant Capacity.Antioxidants (Basel, Switzerland) · 2023Article
- Effect of Acute Cold Stress on Neuroethology in Mice and Establishment of Its Model.Animals : an open access journal from MDPI · 2022Article
- The maternal-placental-fetal interface: Adaptations of the HPA axis and immune mediators following maternal stress and prenatal alcohol exposure.Experimental neurology · 2022Review
- Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation.Clinical epigenetics · 2021Article
- Maternal cold exposure induces distinct transcriptome changes in the placenta and fetal brown adipose tissue in mice.BMC genomics · 2021Article
- Dietary supplementary glutamine and L-carnitine enhanced the anti-cold stress of Arbor Acres broilers.Archives animal breeding · 2021Article
- Gut health, stress, and immunity in neonatal dairy calves: the host side of host-pathogen interactions.Journal of animal science and biotechnology · 2020Review
- Prenatal exposure to particulate air pollution and gestational age at delivery in Massachusetts neonates 2001-2015: A perspective of causal modeling and health disparities.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Characterization of Gut Microbiota in Prenatal Cold Stress Offspring Rats by 16S rRNA Sequencing.Animals : an open access journal from MDPI · 2020Article
- Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe- and CCL2-dependent mechanisms.Translational psychiatry · 2020Article
- Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress.Neuroscience letters · 2019Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal cold stress is one of the earliest factors affecting mammalian health, and is associated with neonatal growth retardation and immune dysfunction, thus increasing disease susceptibility. The mechanisms underlying these observations remain unclear; hence, the objective of this study was to elucidate placental responses to cold stress. 60 maternal rats were randomly allocated to either stressed (n = 30) or non-stressed (control, n = 30) treatment conditions and 30 pubs (n=15) were used for the pups analysis. We found that maternal exposure to cold stress resulted in decreased body temperature, increased food intake without body weight gain, and a high level of plasma corticosterone (CORT) between gestational day (GD) 14 and GD21. In addition, gestation cold stress induced the placental expression of heat shock protein 70 (HSP70), IκBα, glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), interferon (IFN) regulatory factor 3 (IRF3), Caspase-3 proteins and altered the ratio of B-cell lymphoma-extra large (Bcl-xL) to Bcl-associated x (Bax) proteins on gestational GD15, GD17, GD19, and GD21, also resulted in the production of interleukin (IL)-1β. Next, gestational cold stress provoked a decrease in plasma GH levels of 21-day-old offspring, and the body weights of offspring were have no differences from postnatal day (PD) 1-21. Taken together, our results indicate that gestational cold stress induces placental apoptosis and the activation of NF-kB via HSP70/TLR4/NF-κB signaling pathways in the placenta, these changes may affect placental function and fetus development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.