ArticleOncotarget2017
Development of a reliable and accurate algorithm to quantify the tumor immune stroma (QTiS) across tumor types.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Article
- Prognostic value of tumor-infiltrating lymphocytes, tumor associated neutrophils and metabolic checkpoint molecules on survival of patients with metastatic pancreatic ductal adenocarcinoma.Surgery in practice and science · 2025Article
- Differential Immune Infiltration Profiles in Colitis-Associated Colorectal Cancer versus Sporadic Colorectal Cancer.Cancers · 2023Article
- Distinct role of tumor-infiltrating lymphocytes between synchronous and metachronous colorectal cancer.Langenbeck's archives of surgery · 2023Article
- Identification of CT Values That Could Be Predictive of Necrosis (N-CTav) in Hepatocellular Carcinoma after Lenvatinib Treatment.Current oncology (Toronto, Ont.) · 2022Article
- Highly differential count of circulating and tumor infiltrating immune cells in patients with non-HCV/non-HBV hepatocellular carcinoma.Cancer immunology, immunotherapy : CII · 2022Article
- Image-based documentation of vulvodynia pain location.Pain management · 2022Article
- Article
- Changes in Cellular Regulatory Factors before and after Decompression of Odontogenic Keratocysts.Journal of clinical medicine · 2020Article
- Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.EBioMedicine · 2020Article
- Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome.Scientific reports · 2020Article
- Article
- Article
- Apparent Lack ofFrontiers in immunology · 2019Article
- Perivascular Tumor-Infiltrating Leukocyte Scoring for Prognosis of Resected Hepatocellular Carcinoma Patients.Cancers · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor microenvironment plays an important role in the tumor biology. Overall survival of tumor patients after resection is influenced by tumor-infiltrating lymphocytes (TILs) as a component of the tumor stroma. However, it is not clear how to assess TILs in the tumor stroma due to heterogeneous methods in different cancer types. Therefore, we present a novel Quantification of the Tumor immune Stroma (QTiS) Algorithm to reliably and accurately quantify cells in the tumor stroma. Immunohistochemical staining of CD3 and CD8 cells in sections of metastatic colorectal cancer (mCRC), ovarian cancer (OvCa), hepatocellular carcinoma (HCC), and pancreatic ductal adenocarcinoma (PDAC), alltogether
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