Evidence map›Paper›PMID 29383012›Full record

ArticleDose-response : a publication of International Hormesis Society

Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats.

Richard Smith, Jiaxi Wang, Colin Seymour, Cristian Fernandez-Palomo, Jennifer Fazzari, Elisabeth Schültke, Elke Bräuer-Krisch, Jean Laissue, Christian Schroll, Carmel Mothersill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard SmithDepartment of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-8950-2386
Jiaxi WangMass Spectrometry Facility, Department of Chemistry, Queen's University, Kingston, Ontario, Canada.
Colin SeymourDepartment of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.
Cristian Fernandez-PalomoDepartment of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-5095-262X
Jennifer FazzariDepartment of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.
Elisabeth SchültkeDepartment of Radio-oncology, Rostock University Medical Centre, Rostock, Germany.
Elke Bräuer-KrischEuropean Synchrotron Radiation Facility, Grenoble, France.
Jean LaissueInstitute of Pathology, University of Bern, Bern, Switzerland.
Christian SchrollStereotactic Neurosurgery and Laboratory for Molecular Neurosurgery, Freiburg University Medical Centre, Freiburg, Germany.
Carmel MothersillDepartment of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated. Adult rats were irradiated with 35 or 350 Gy at the European Synchrotron Research Facility using homogenous irradiation (HR) or MRT to the right brain hemisphere. The irradiated rats were housed with nonirradiated rats. After 48 hours, all rats were euthanized and the frontal lobe proteome was analyzed using 2-dimensional electrophoresis and mass spectrometry. Proteome changes were determined by analysis of variance (

Indexed as

antitumorigenesisbystander effecthomogenous irradiationmicrobeam irradiationproteomics

Identifiers

PMID29383012
PMCPMC5784471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.