Evidence map›Paper›PMID 29383007›Full record

Observational studyMolecular vision2018

Myopia in Chinese families shows linkage to 10q26.13.

Anthony M Musolf, Claire L Simpson, Kyle A Long, Bilal A Moiz, Deyana D Lewis, Candace D Middlebrooks, Laura Portas, Federico Murgia, Elise B Ciner, Joan E Bailey-Wilson and 1 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC
In one paragraph

Observational study in Molecular vision, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Myopia in African Americans Is Significantly Linked to Chromosome 7p15.2-14.2.Investigative ophthalmology & visual science · 2021
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anthony M MusolfComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Claire L SimpsonDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN.
Kyle A LongComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Bilal A MoizComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Deyana D LewisComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Candace D MiddlebrooksComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Laura PortasInstitute of Population Genetics, CNR, Li Punti, Sassari, Italy.
Federico MurgiaInstitute of Population Genetics, CNR, Li Punti, Sassari, Italy.
Elise B CinerThe Pennsylvania College of Optometry at Salus University, Elkins Park, PA.
Joan E Bailey-WilsonComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD.
Dwight StambolianDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, PA.
National Human Genome Research Institute · USNational Institutes of Health · USUniversity of Pennsylvania · US

Funding

Genetic Epidemiology of Complex TraitsZIAHG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$10.5M
Genetic Epidemiology of Refractive ErrorR01EY020483 · NEI · UNIVERSITY OF PENNSYLVANIA · PI STAMBOLIAN, DWIGHT EDWARD · 2010 to 2014
$2.9M
NEI NIH HHS R01 EY020483
6 · The paper itself

Abstract

Purpose: To determine genetic linkage between myopia and Han Chinese patients with a family history of the disease. Methods: One hundred seventy-six Han Chinese patients from 34 extended families were given eye examinations, and mean spherical equivalent (MSE) in diopters (D) was calculated by adding the spherical component of the refraction to one-half the cylindrical component and taking the average of both eyes. The MSE was converted to a binary phenotype, where all patients with an MSE of -1.00 D or less were coded as affected. Unaffected individuals had an MSE greater than 0.00 D (ages 21 years and up), +1.50 (ages 11-20), or +2.00 D (ages 6-10 years). Individuals between the given upper threshold and -1.00 were coded as unknown. Patients were genotyped on an exome chip. Three types of linkage analyses were performed: single-variant two-point, multipoint, and collapsed haplotype pattern (CHP) variant two-point. Results: The CHP variant two-point results identified a significant peak (heterogeneity logarithm of the odds [HLOD] = 3.73) at 10q26.13 in Conclusions: We report a significant genetic linkage between myopia and Han Chinese patients at 10q26.13. 10q26.13 contains several good candidate genes, such as

Indexed as

Genetic LinkageGenetic LociGenetic Predisposition to DiseaseAdultAgedAsian PeopleCarrier ProteinsChildChromosomes, Human, Pair 10FamilyFemaleHaplotypesHigh-Temperature Requirement A Serine Peptidase 1HumansMaleMyopiaCarrier ProteinsHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanTACC2 protein, humanTumor Suppressor Proteins

Identifiers

PMID29383007
PMCPMC5767476
OpenAlexW2795561290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.