Evidence map›Paper›PMID 29382964›Full record

Trial reportCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2018

Safety evaluation of a new anxiolytic product containing botanicals

Aleksandar Masic, Rui Liu, Kristen Simkus, Jeff Wilson, John Baker, Pablo Sanchez, Ammar Saleem, Cory C Harris, Tony Durst, John T Arnason

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC
In one paragraph

Trial report in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03904511 (Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03904511 phase1completednot on this mapstarted 2019, after this paper: background citation

Safety, Tolerability and Behavioural Effects of Souroubea-Platanus in Healthy Volunteers

TypeinterventionalSponsorUniversity of OttawaRan2019 to 2020Enrolled45ConditionsAnxiety, Stress, PsychologicalArmsSouroubea-Platanus Preparation, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Aleksandar MasicCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Rui LiuCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Kristen SimkusCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Jeff WilsonCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
John BakerCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Pablo SanchezCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Ammar SaleemCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Cory C HarrisCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Tony DurstCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
John T ArnasonCancog Tecnologies, 120 Carlton Street, Toronto, Ontario M5A 4K2, Canada (Masic); Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5 (Liu, Saleem, Harris, Durst, Arnason); Novometrix Research, Moffat, Ontario L0P 1J0 (Simkus, Wilson); Stonehedge Bioresources, Stirling, Ontario (Baker); Universidad Nacional, Heredia, Costa Rica (Sanchez).
Universidad Nacional · CRUniversity of Ottawa · CAUniversity of Stirling · GBZeptoMetrix (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Separation anxiety and noise aversion are common behavioral problems in dogs. They elicit fear responses such as cowering, seeking out the owner, and attempting to escape. This can result in property damage, injury to the dog, and disruption of the owner-pet bond, possibly leading to pet abandonment or euthanasia. A novel botanical anxiolytic product was evaluated for safety in dogs as the target animal species. Its intended use is for the treatment and prevention of anxiety and noise aversion in dogs. It contains a defined mixture of

Indexed as

AnimalsAnti-Anxiety AgentsBetulinic AcidDogsDouble-Blind MethodEricalesMagnoliopsidaMalePentacyclic TriterpenesPlant BarkPlant PreparationsPlants, MedicinalTriterpenesAnti-Anxiety AgentsBetulinic AcidPentacyclic TriterpenesPlant PreparationsTriterpenes

Identifiers

PMID29382964
PMCPMC5764046
OpenAlexW2980481950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.