Evidence map›Paper›PMID 29382962›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering

Microscopic validation of whole mouse micro-metastatic tumor imaging agents using cryo-imaging and sliding organ image registration.

Yiqiao Liu, Bo Zhou, Mohammed Qutaish, David L Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yiqiao LiuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Bo ZhouDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
Mohammed QutaishDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
David L WilsonDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.

Funding

Cancer Imaging and Therapy Analysis Platform (CITAP)R44CA213601 · NCI · BIOINVISION, INC. · PI GARGESHA, MADHUSUDHANA, WILSON, DAVID LYNN · 2018 to 2019
$1.6M
Cancer Imaging and Therapy PlatformR41CA213601 · NCI · BIOINVISION, INC. · PI WILSON, DAVID LYNN · 2016 to 2016
$224k
NCI NIH HHS R41 CA213601NCI NIH HHS R44 CA213601
6 · The paper itself

Abstract

We created a metastasis imaging, analysis platform consisting of software and multi-spectral cryo-imaging system suitable for evaluating emerging imaging agents targeting micro-metastatic tumor. We analyzed CREKA-Gd in MRI, followed by cryo-imaging which repeatedly sectioned and tiled microscope images of the tissue block face, providing anatomical bright field and molecular fluorescence, enabling 3D microscopic imaging of the entire mouse with single metastatic cell sensitivity. To register MRI volumes to the cryo bright field reference, we used our

Indexed as

cryo-imagingMicro-metastases imagingMRI contrast agentparameters optimizationsliding organ registration

Identifiers

PMID29382962
PMCPMC5787390

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.