ArticleScientific reports2018
JhI-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
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- Internal sensory neurons regulate stage-specific growth in Drosophila.Development (Cambridge, England) · 2022Article
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.PLoS genetics · 2021Article
- Vitamin A deficiency affects gene expression in the Drosophila melanogaster head.G3 (Bethesda, Md.) · 2021Article
- Gene expression and alternative splicing dynamics are perturbed in female head transcriptomes following heterospecific copulation.BMC genomics · 2021Article
- The Nutrient-Responsive Molecular Chaperone Hsp90 Supports Growth and Development inFrontiers in physiology · 2021Article
- Growth regulation by amino acid transporters in Drosophila larvae.Cellular and molecular life sciences : CMLS · 2020Review
- Regulation of Body Size and Growth Control.Genetics · 2020Review
- Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.Annual review of physiology · 2020Review
- Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth.Cell reports · 2018Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Insulin is present all across the animal kingdom. Its proper release after feeding is of extraordinary importance for nutrient uptake, regulation of metabolism, and growth. We used Drosophila melanogaster to shed light on the processes linking dietary leucine intake to insulin secretion. The Drosophila genome encodes 8 insulin-like peptides ("Dilps"). Of these, Dilp2 is secreted after the ingestion of a leucine-containing diet. We previously demonstrated that Minidiscs, related to mammalian system-L transporters, acts as a leucine sensor within the Dilp2-secreting insulin-producing cells ("IPCs") of the brain. Here, we show that a second leucine transporter, JhI-21, of the same family is additionally necessary for proper leucine sensing in the IPCs. Using calcium imaging and ex-vivo cultured brains we show that knockdown of JhI-21 in IPCs causes malfunction of these cells: they are no longer able to sense dietary leucine or to release Dilp2 in a leucine dependent manner. JhI-21 knockdown in IPCs further causes systemic metabolic defects including defective sugar uptake and altered growth. Finally, we showed that JhI-21 and Minidiscs have no cumulative effect on Dilp2 release. Since system-L transporters are expressed by mammalian β-cells our results could help to better understand the role of these proteins in insulin signaling.
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