ArticleEuropean journal of clinical nutrition2018
Effect of a fish oil-based lipid emulsion on intestinal failure-associated liver disease in children.
Article in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Effects of Vitamin DNutrients · 2022Trial
- Potential Beneficial Effects of Crab-Flavored Seafood Intake in Young Rats.Nutrition and metabolic insights · 2024Article
- Improvement in Intestinal-Failure-Associated Liver Disease by Using Parenteral Fish Oil as Monotherapy: Case-Based Review of the Literature.Reports (MDPI) · 2023Article
- [Prevention and treatment strategies for intestinal failure-associated liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Intestinal Continuity Alleviates Pediatric Intestinal Failure-Associated Liver Disease.Frontiers in surgery · 2022Article
- Long-term outcomes of various pediatric short bowel syndrome in China.Pediatric surgery international · 2021Article
- Intravenous Lipid Emulsions in the Prevention and Treatment of Liver Disease in Intestinal Failure.Nutrients · 2021Review
- Effect of fish paste products, fish balls 'tsumire', intake in Sprague-Dawley rats.Journal of nutritional science · 2021Article
- Article
- Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management.Hepatology international · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe aim of this study was to assess the effects of a fish oil-based lipid emulsion on intestinal failure-associated liver disease (IFALD) in children. SUBJECTS/
methodsFrom January 2014 through June 2017, we enrolled 32 children with IF on long-term parenteral nutrition (PN). When the levels of any three of seven liver indicators (TBA, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, gamma glutamyl transferase (γ-GT), total bilirubin (TB), or direct bilirubin (DB)) were two times higher than normal levels, we switched a 50:50 mix of soybean oil and medium-chain triglycerides (MCT) lipid emulsion (with an average dose of 1.30 g/kg/day) to a fish oil-based lipid emulsion (1 g/kg/day) and measured liver function in the children. Meanwhile, inflammation and oxidative stress-related markers were also measured.
resultsThe average fish oil therapy duration was 26 ± 21 days, and the median duration of PN support was 84 days. With fish oil therapy, levels of TBA, ALT, AST, γ-GT, TB, and DB all significantly decreased. Enteral nutrition was introduced following fish oil resulting in higher energy intake (99.88 ± 31.06 kcal/kg/day) compared with before fish oil (67.90 ± 27.31 kcal/kg/day, P = 0.001). No significant difference was found in average PN energy (P = 0.147). In addition, levels of inflammatory indicators like tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and white blood cell (WBC) significantly decreased.
conclusionsFish oil therapy alleviates IFALD in children.
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