Evidence map›Paper›PMID 29382920›Full record

ArticleJournal of human genetics2018

A systematic analysis highlights multiple long non-coding RNAs associated with cardiometabolic disorders.

Mohsen Ghanbari, Marjolein J Peters, Paul S de Vries, Cindy G Boer, Jeroen G J van Rooij, Yu-Chi Lee, Vinod Kumar, André G Uitterlinden, M Arfan Ikram, Cisca Wijmenga and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  12. Into the Wild: GWAS Exploration of Non-coding RNAs.Frontiers in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. m.ghanbari@erasmusmc.nl.
Marjolein J Peters *Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Paul S de Vries *Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Cindy G BoerDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jeroen G J van RooijDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Yu-Chi LeeNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Vinod KumarDepartment of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Cisca WijmengaDepartment of Genetics, University Medical Center Groningen, Groningen, The Netherlands.
Jose M OrdovasNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Caren E SmithNutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Joyce B J van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stefan J ErkelandDepartment of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. a.dehghan@imperial.ac.uk.
Erasmus MC · NLUniversity Medical Center Groningen · NLImperial College London · GBJean Mayer Human Nutrition Research Center on Aging · USSpanish National Centre for Cardiovascular Research · ESThe University of Texas Health Science Center at Houston · USTufts University · US

Funding

Genetic predictors of metabolic responses to dairyK08HL112845 · NHLBI · TUFTS UNIVERSITY BOSTON · PI SMITH, CAREN ELIZABETH · 2013 to 2017
$474k
NHLBI NIH HHS K08 HL112845
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified many susceptibility loci for cardiometabolic disorders. Most of the associated variants reside in non-coding regions of the genome including long non-coding RNAs (lncRNAs), which are thought to play critical roles in diverse biological processes. Here, we leveraged data from the available GWAS meta-analyses on lipid and obesity-related traits, blood pressure, type 2 diabetes, and coronary artery disease and identified 179 associated single-nucleotide polymorphisms (SNPs) in 102 lncRNAs (p-value < 2.3 × 10

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseComputational BiologyDNA MethylationEpigenesis, GeneticEpistasis, GeneticGene Expression ProfilingGene Expression RegulationGenetic VariationGenome-Wide Association StudyHeart DiseasesHumansMetabolic DiseasesMicroRNAsMolecular Sequence AnnotationNucleic Acid ConformationMicroRNAsRNA, Long Noncoding

Identifiers

PMID29382920
PMCPMC6894420
OpenAlexW2787847133

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.