Evidence map›Paper›PMID 29382847›Full record

ArticleNature communications2018

Activated CD8

Naohiro Seo, Yoshitaka Shirakura, Yoshiro Tahara, Fumiyasu Momose, Naozumi Harada, Hiroaki Ikeda, Kazunari Akiyoshi, Hiroshi Shiku

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Towards liquid biopsy-based analysis of antitumour immunity.Nature reviews. Clinical oncology · 2026
    Review
  4. Review
  5. Extracellular vesicles: Navigating new frontiers in glioblastoma therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
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  17. Article
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naohiro SeoDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, 514-8507, Japan. seo-naohiro@clin.medic.mie-u.ac.jp.
Yoshitaka ShirakuraDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, 514-8507, Japan.
Yoshiro TaharaERATO Bio-Nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto, 615-8530, Japan.
Fumiyasu MomoseDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, 514-8507, Japan.
Naozumi HaradaDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, 514-8507, Japan.
Hiroaki IkedaDepartment of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, 852-8523, Japan.
Kazunari AkiyoshiERATO Bio-Nanotransporter Project, Japan Science and Technology Agency (JST), Kyoto, 615-8530, Japan.
Hiroshi ShikuDepartment of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, 514-8507, Japan. shiku@clin.medic.mie-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblastic tumour stroma comprising mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promotes the invasive and metastatic properties of tumour cells. Here we show that activated CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell Line, TumorCells, CulturedCell SurvivalExtracellular VesiclesFemaleMesenchymal Stem CellsMice, Inbred BALB CNeoplasms, Experimental

Identifiers

PMID29382847
PMCPMC5789986

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.