Evidence map›Paper›PMID 29382818›Full record

ArticleNature communications2018

Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.

Héctor Sánchez-Iranzo, María Galardi-Castilla, Carolina Minguillón, Andrés Sanz-Morejón, Juan Manuel González-Rosa, Anastasia Felker, Alexander Ernst, Gabriela Guzmán-Martínez, Christian Mosimann, Nadia Mercader

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Mechanisms and Therapeutic Potential of Human Cardiomyocyte Proliferation.Journal of cardiovascular development and disease · 2026
    Review
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  7. Article
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  15. Article
  16. Review
  17. In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Héctor Sánchez-IranzoDevelopment of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain.
María Galardi-CastillaDevelopment of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain.
Carolina MinguillónCSIC-Institut de Biologia Molecular de Barcelona Parc Científic de Barcelona C/ Baldiri i Reixac, 10 08028, Barcelona, Spain.
Andrés Sanz-MorejónDevelopment of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain.
Juan Manuel González-RosaDevelopment of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain.
Anastasia FelkerInstitute of Molecular Life Sciences, University of Zürich, 8057, Zürich, Switzerland.
Alexander ErnstInstitute of Anatomy, University of Bern, 3000, Bern 9, Switzerland.
Gabriela Guzmán-MartínezHospital Universitario La Paz, IdiPAZ, 28046, Madrid, Spain.
Christian MosimannInstitute of Molecular Life Sciences, University of Zürich, 8057, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-0749-2576
Nadia MercaderDevelopment of the Epicardium and Its Role during Regeneration Group, Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII), Melchor Fernández Almagro 3, 28029, Madrid, Spain. nadia.mercader@ana.unibe.ch.ORCID http://orcid.org/0000-0002-0905-6399
University of Bern · CHInstituto de Salud Carlos III · ESUniversity of Zurich · CHHarvard University · USHospital Universitario La Paz · ESPasqual Maragall Foundation · ES

Funding

European Research Council 337703
6 · The paper itself

Abstract

During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field (SHF) are added. The contribution of FHF and SHF progenitors to the adult zebrafish heart has not been studied to date. Here we find, using genetic tbx5a lineage tracing tools, that the ventricular myocardium in the adult zebrafish is mainly derived from tbx5a

Indexed as

AnimalsAnimals, Genetically ModifiedCell DifferentiationCell LineageCell TrackingEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGenes, ReporterGreen Fluorescent ProteinsHeart VentriclesLuminescent ProteinsMyocardiumMyocytes, CardiacMyosin Light ChainsOrganogenesisRed Fluorescent ProteinGreen Fluorescent ProteinsLuminescent ProteinsMyosin Light ChainsRed Fluorescent ProteinT-Box Domain ProteinsT-box transcription factor 5

Identifiers

PMID29382818
PMCPMC5789846
OpenAlexW2800724100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.