ArticleProceedings of the National Academy of Sciences of the United States of America2018
Farming the mitochondrial ancestor as a model of endosymbiotic establishment by natural selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed.
- Host-initiated microbial association leads to stable ectosymbiosis in an ecological model.PLoS computational biology · 2026Article
- Phagocytosis of microbial symbionts supports embryonic nutrition in the sponge Halichondria panicea.Microbiome · 2026Article
- Quantifying the fitness contribution of phagocytosis.bioRxiv : the preprint server for biology · 2025Article
- Quantifying the evolutionary paths to endomembranes.Cell reports · 2025Article
- Review
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Genesis of ectosymbiotic features based on commensalistic syntrophy.Scientific reports · 2024Article
- Eco-evolutionary modelling of microbial syntrophy indicates the robustness of cross-feeding over cross-facilitation.Scientific reports · 2023Article
- Review
- Closing the energetics gap.Nature ecology & evolution · 2022Article
- The Asgard Archaeal-Unique Contribution to Protein Families of the Eukaryotic Common Ancestor Was 0.3.Genome biology and evolution · 2021Article
- Association with a novel protective microbe facilitates host adaptation to a stressful environment.Evolution letters · 2021Article
- Endosymbiosis before eukaryotes: mitochondrial establishment in protoeukaryotes.Cellular and molecular life sciences : CMLS · 2020Review
- Tracking intra- and inter-organelle signaling of mitochondria.The FEBS journal · 2019Review
- Energy metabolism in anaerobic eukaryotes and Earth's late oxygenation.Free radical biology & medicine · 2019Review
- Multilevel selection as Bayesian inference, major transitions in individuality as structure learning.Royal Society open science · 2019Article
- Proposal of the reverse flow model for the origin of the eukaryotic cell based on comparative analyses of Asgard archaeal metabolism.Nature microbiology · 2019Article
- Structural Patching Fosters Divergence of Mitochondrial Ribosomes.Molecular biology and evolution · 2019Article
- Can a Symbiont (Also) Be Food?Frontiers in microbiology · 2019Article
- Evolutionary origins and specialisation of membrane transport.Current opinion in cell biology · 2018Review
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Abstract
The origin of mitochondria was a major evolutionary transition leading to eukaryotes, and is a hotly debated issue. It is unknown whether mitochondria were acquired early or late, and whether it was captured via phagocytosis or syntrophic integration. We present dynamical models to directly simulate the emergence of mitochondria in an ecoevolutionary context. Our results show that regulated farming of prey bacteria and delayed digestion can facilitate the establishment of stable endosymbiosis if prey-rich and prey-poor periods alternate. Stable endosymbiosis emerges without assuming any initial metabolic benefit provided by the engulfed partner, in a wide range of parameters, despite that during good periods farming is costly. Our approach lends support to the appearance of mitochondria before any metabolic coupling has emerged, but after the evolution of primitive phagocytosis by the urkaryote.
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