Evidence map›Paper›PMID 29382737›Full record

ArticlemBio2018

UDP-Glucuronic Acid Transport Is Required for Virulence of

Lucy X Li, Carsten Rautengarten, Joshua L Heazlewood, Tamara L Doering

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  13. Dangerous Liaisons: Interactions ofPathogens (Basel, Switzerland) · 2020
    Review
  14. Article
  15. Article
  16. Review
  17. Conserved Glu-47 and Lys-50 residues are critical for UDP-The Journal of biological chemistry · 2019
    Article
  18. Article
  19. Review
  20. Peeling the onion: the outer layers of Cryptococcus neoformans.Memorias do Instituto Oswaldo Cruz · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Lucy X LiDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Carsten RautengartenSchool of Biosciences, University of Melbourne, Melbourne, Australia.
Joshua L HeazlewoodSchool of Biosciences, University of Melbourne, Melbourne, Australia.
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA doering@wustl.edu.ORCID 0000-0002-5179-7393
The University of Melbourne · AUWashington University in St. Louis · US

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
CAPSULE REGULATION AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANSR01AI087794 · NIAID · WASHINGTON UNIVERSITY · PI BRENT, MICHAEL R, DOERING, TAMARA L · 2011 to 2020
$4.1M
CRYPTOCOCCAL INTERACTIONS WITH HOST CELLSR01AI078795 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2009 to 2013
$2.0M
Synthesis &transport of cryptococcal capsule precursorsR01GM066303 · NIGMS · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2002 to 2005
$1.1M
Expanding Access to Planar Illumination Microscopy in a Neuroimaging CoreR24NS086741 · NINDS · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 2014 to 2017
$814k
GLYCAN PRECURSOR TRANSPORT IN CRYPTOCOCCUS NEOFORMANSR21AI109623 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2014 to 2015
$419k
Role of glycan precursor transporters in Cryptococcus neoformans virulenceF30AI120339 · NIAID · WASHINGTON UNIVERSITY · PI LI, LUCY · 2016 to 2018
$128k
NIAID NIH HHS F30 AI120339NIAID NIH HHS R01 AI078795NIAID NIH HHS R01 AI087794NIAID NIH HHS R21 AI109623NIGMS NIH HHS R01 GM066303NIGMS NIH HHS T32 GM007200NINDS NIH HHS R24 NS086741
6 · The paper itself

Abstract

Glycans play diverse biological roles, ranging from structural and regulatory functions to mediating cellular interactions. For pathogens, they are also often required for virulence and survival in the host. In

Indexed as

AnimalsBiological TransportColony Count, MicrobialCryptococcosisCryptococcus neoformansDisease Models, AnimalGene DeletionHumansLungMembrane Transport ProteinsMiceSurvival AnalysisUridine Diphosphate Glucuronic AcidVirulenceMembrane Transport ProteinsUridine Diphosphate Glucuronic AcidCryptococcus neoformansfungal pathogenesisglycan synthesisnucleotide sugar transporterpolysaccharide capsuleUDP-glucuronic acid

Identifiers

PMID29382737
PMCPMC5790919
OpenAlexW2786776154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.