Evidence map›Paper›PMID 29382734›Full record

ArticlemBio2018

Conditional Protein Splicing Switch in Hyperthermophiles through an Intein-Extein Partnership.

Christopher W Lennon, Matthew Stanger, Nilesh K Banavali, Marlene Belfort

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Conditional protein splicing of thebioRxiv : the preprint server for biology · 2024
    Article
  6. Massive intein content inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Gold Nanoparticles Augment N-Terminal Cleavage and Splicing Reactions inFrontiers in bioengineering and biotechnology · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Efficient Generation of Hydrazides in Proteins by RadA Split Intein.Chembiochem : a European journal of chemical biology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher W LennonDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Matthew StangerDepartment of Biological Sciences, University at Albany, Albany, New York, USA.
Nilesh K BanavaliDepartment of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA.
Marlene BelfortDepartment of Biological Sciences, University at Albany, Albany, New York, USA mbelfort@albany.edu.
University at Albany, State University of New York · US

Funding

SELF-SPLICING INTEINS: FUNCTION, EVOLUTION, APPLICATIONR01GM044844 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1990 to 2019
$8.9M
SELF-SPLICING INTRONS IN THE PHAGE T4/E COLI SYSTEMR01GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 1988 to 2019
$5.3M
INTRON DYNAMICS IN BACTERIAR37GM039422 · NIGMS · WADSWORTH CENTER · PI BELFORT, MARLENE · 2001 to 2010
$4.0M
Post-translational regulation of recombinase function by intein splicingF32GM121000 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LENNON, CHRISTOPHER WILLIAM · 2016 to 2017
$119k
NIGMS NIH HHS F32 GM121000NIGMS NIH HHS R01 GM039422NIGMS NIH HHS R01 GM044844NIGMS NIH HHS R37 GM039422
6 · The paper itself

Abstract

Inteins are intervening proteins that undergo an autocatalytic splicing reaction that ligates flanking host protein sequences termed exteins. Some intein-containing proteins have evolved to couple splicing to environmental signals; this represents a new form of posttranslational regulation. Of particular interest is RadA from the archaeon

Indexed as

ExteinsInteinsProtein SplicingArchaeal ProteinsDNA-Binding ProteinsModels, BiologicalModels, MolecularPyrococcus horikoshiiSequence DeletionTemperatureThermococcusArchaeal ProteinsDNA-Binding ProteinsRadA protein, archaealhyperthermophilemobile genetic elementsPosttranslational regulationrecombinase

Identifiers

PMID29382734
PMCPMC5790916
OpenAlexW2793407638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.